Synthesis and characterization of amino and cyano-functionalized zinc-terephthalate metal–organic frameworks for loading of piroxicam drug

A. C. Tella, S. E. Eliagwu, M. Amali, A. T. Kola-Mustapha, S. J. Olatunji, F. Ishola, V. O. Adimula, O. S. Oluwafemi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Abstract: Piroxicam is a member of the oxicam group known to be nonsteroidal anti-inflammatory drugs (NSAID) which are used in the treatment of pain and arthritis. To improve its effectiveness and lessen the occurrence of side effects, the need to develop drug carrier systems tuned towards improved loading capability and controlled release is imperative. We herein report the synthesis of the zinc-terephthalate metal–organic frameworks (MOFs) and its functionalization by incorporation of amino and cyano groups using ethylenediamine (en) and malononitrile (MN), respectively, for the delivery of piroxicam drug. The functionalized and unfunctionalized MOFs were characterized using elemental analysis, Fourier transforms infrared spectroscopy (FTIR), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET) and Powder X-ray diffraction (PXRD). BET analysis showed that the zinc terephthalate, zinc terephthalate–en and zinc terephthalate–MN have a surface area and total pore volume of 3130 m2/g (1.437 cm3/g), 3069 m2/g (1.361 cm3/g) and 2975 m2/g (1.232 cm3/g), respectively. The amounts of drug (Piroxicam) loaded on zinc terephthalate and zinc terephthalate–en are 92.06 wt% and 95.23 wt%, respectively. This work reveals that the as-synthesized functionalized MOFs can serve as promising candidates for the delivery of the piroxicam drug and other nonsteroidal anti-inflammatory drugs. Graphic abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)2287-2296
Number of pages10
JournalChemical Papers
Volume74
Issue number7
DOIs
Publication statusPublished - 1 Jul 2020

Keywords

  • Functionalization
  • Metal–organic frameworks
  • Pharmaceutical
  • Scanning electron microscopy

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry
  • General Chemical Engineering
  • Industrial and Manufacturing Engineering
  • Materials Chemistry

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