Supramolecular drug delivery platforms in photodynamic therapy

T. G. St Denis, M. R. Hamblin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

8 Citations (Scopus)


Photodynamic therapy (PDT) involves the photonic excitation of a photosensitizer (PS) dye in the presence of ambient oxygen, in turn forming reactive oxygen species that kill undesired cells. Many conventional PS possess organic frameworks that are hydrophobic and consequently prone to aggregation in solution which both alters photophysical characteristics of the dyes and prevents desired PS localization at target cells. Though chemical modification has traditionally been used to alter PS solubility and improve drug targeting, recently the prospect of using self-assembling supramolecular liposomal and nonliposomal delivery platforms has emerged as a method for drastically improving PS drug delivery. This chapter reviews liposomal dug delivery systems as well as nonliposomal systems including polymeric micelles, block copolymers, polymersomes, fullerosomes, nanocells, nanoemulsions, and lipoplexes. As PDT emerges as a viable clinical tool for the treatment of malignant as well as other diseases, modes of improving PS localization will become increasing relevant.

Original languageEnglish
Title of host publicationApplications of Nanoscience in Photomedicine
PublisherElsevier Inc.
Number of pages21
ISBN (Electronic)9781908818782
ISBN (Print)9781907568671
Publication statusPublished - 3 Feb 2015
Externally publishedYes


  • Block copolymers
  • Fullerosomes
  • Lipoplexes
  • Micelles
  • Nanocells
  • Nanoemulsions
  • Polymerosomes

ASJC Scopus subject areas

  • General Medicine


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