Studies on curcumin loaded poly(n -isopropylacrylamide) silver nanocomposite hydrogels for antibacterial and drug releasing applications

Sakey Ravindra, Kokkarachedu Varaprasad, V. Rajinikanth, Antoine F. Mulaba-Bafubiandi, Koduri Venkata Surya Ramam

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Design of silver nanoparticles containing poly(N-isopropylarclamide) (PNIPAAm) hydrogels were prepared by free-radical polymerization of N-isopropylarclamide as an environmentally sensitive monomer and MBA as a crosslinker in an aqueous medium. The embedded silver nanocomposite hydrogels (AgNCH) structure were characterized by, UV-Vis, FTIR, DLS, TEM and X-ray analysis. Curcumin loading and release characteristics were performed for PNIPAAm hydrogel, silver ions loaded hydrogels as well as silver nanocomposite hydrogels. These curcumin loaded silver nanocomposite hydrogels exhibit excellent antibacterial action on Escherichia coli (E. coli). Therefore, the present study clearly provides novel antimicrobial hydrogels which are potentially useful in biomedical applications.

Original languageEnglish
Pages (from-to)1230-1240
Number of pages11
JournalJournal of Macromolecular Science - Pure and Applied Chemistry
Volume50
Issue number12
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

  • Silver nanocomposites
  • antibacterial activity
  • curcumin
  • hydrogels

ASJC Scopus subject areas

  • Ceramics and Composites
  • General Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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