Structural load-bearing characteristics of biopolymer in situ-forming hydrogels for ophthalmic drug delivery

Ophthalmic drug delivery has been a field of continuous innovation, aiming to overcome the unique challenges posed by the ocular environment. In this chapter, we delve into the intricate world of biopolymer-based in situ-forming hydrogels as novel drug delivery carriers for ophthalmic applications. These hydrogels exhibit remarkable structural load-bearing properties that have the potential to revolutionize the landscape of ocular drug delivery. A significant focus of this chapter is the comprehensive analysis of the structural characteristics and load-bearing capabilities of these hydrogels. Through an array of experimental techniques, including rheological assessments, and mechanical testing, we dissect the mechanical attributes of these hydrogels. We highlight the importance of their viscoelastic behavior and resilience in withstanding dynamic forces within the intricate ocular milieu. Furthermore, we discuss the implications of these structural load-bearing properties in the context of ophthalmic drug delivery. The ability of biopolymer-based hydrogels to provide sustained drug release while maintaining their structural integrity in the challenging ocular environment underscores their potential to enhance patient compliance and therapeutic outcomes. This chapter is a comprehensive guide for researchers, clinicians, and pharmaceutical scientists interested in the burgeoning field of biopolymer-based in situ-forming hydrogels for ophthalmic drug delivery. It underscores the pivotal role of structural load-bearing characteristics in shaping the future of ocular drug delivery strategies, offering promising avenues for improved patient care and treatment efficacy.