TY - JOUR
T1 - Stimulus-responsive sequential release systems for drug and gene delivery
AU - Ahmadi, Sepideh
AU - Rabiee, Navid
AU - Bagherzadeh, Mojtaba
AU - Elmi, Faranak
AU - Fatahi, Yousef
AU - Farjadian, Fatemeh
AU - Baheiraei, Nafiseh
AU - Nasseri, Behzad
AU - Rabiee, Mohammad
AU - Dastjerd, Niloufar Tavakoli
AU - Valibeik, Ali
AU - Karimi, Mahdi
AU - Hamblin, Michael R.
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/10
Y1 - 2020/10
N2 - In recent years, a range of studies have been conducted with the aim to design and characterize delivery systems that are able to release multiple therapeutic agents in controlled and programmed temporal sequences, or with spatial resolution inside the body. This sequential release occurs in response to different stimuli, including changes in pH, redox potential, enzyme activity, temperature gradients, light irradiation, and by applying external magnetic and electrical fields. Sequential release (SR)-based delivery systems, are often based on a range of different micro- or nanocarriers and may offer a silver bullet in the battle against various diseases, such as cancer. Their distinctive characteristic is the ability to release one or more drugs (or release drugs along with genes) in a controlled sequence at different times or at different sites. This approach can lengthen gene expression periods, reduce the side effects of drugs, enhance the efficacy of drugs, and induce an anti-proliferative effect on cancer cells due to the synergistic effects of genes and drugs. The key objective of this review is to summarize recent progress in SR-based drug/gene delivery systems for cancer and other diseases.
AB - In recent years, a range of studies have been conducted with the aim to design and characterize delivery systems that are able to release multiple therapeutic agents in controlled and programmed temporal sequences, or with spatial resolution inside the body. This sequential release occurs in response to different stimuli, including changes in pH, redox potential, enzyme activity, temperature gradients, light irradiation, and by applying external magnetic and electrical fields. Sequential release (SR)-based delivery systems, are often based on a range of different micro- or nanocarriers and may offer a silver bullet in the battle against various diseases, such as cancer. Their distinctive characteristic is the ability to release one or more drugs (or release drugs along with genes) in a controlled sequence at different times or at different sites. This approach can lengthen gene expression periods, reduce the side effects of drugs, enhance the efficacy of drugs, and induce an anti-proliferative effect on cancer cells due to the synergistic effects of genes and drugs. The key objective of this review is to summarize recent progress in SR-based drug/gene delivery systems for cancer and other diseases.
KW - Cancer nanomedicine
KW - Sequential drug and gene release
KW - Stimulus-responsive nanoparticles
KW - Synergistic combinations
KW - Temporal control
UR - http://www.scopus.com/inward/record.url?scp=85087278714&partnerID=8YFLogxK
U2 - 10.1016/j.nantod.2020.100914
DO - 10.1016/j.nantod.2020.100914
M3 - Review article
AN - SCOPUS:85087278714
SN - 1748-0132
VL - 34
JO - Nano Today
JF - Nano Today
M1 - 100914
ER -
