Spectroscopic characterization and antimicrobial activity of nanoparticle doped cyclodextrin polyurethane bionanosponge

Anny Leudjo Taka, Bryan P. Doyle, Emanuela Carleschi, Thierry Youmbi Fonkui, Rudolph Erasmus, Elvis Fosso-Kankeu, Kriveshini Pillay, Xavier Y. Mbianda

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

This study reports on the spectroscopic characterization and antimicrobial potency of polyurethane cyclodextrin co-polymerized phosphorylated multiwalled carbon nanotube-doped Ag-TiO2 nanoparticle (pMWCNT-CD/Ag-TiO2) bionanosponge nanocomposite. The synthesis of pMWCNT-CD/Ag-TiO2 bionanosponge nanocomposite was carried out through the combined processes of amidation and polymerization reactions as well as the sol-gel method. The native nanosponge cyclodextrin and phosphorylated multiwalled carbon nanotube–nanosponge CD (pMWCNT-CD) polyurethanes were also prepared, and their antimicrobial activities carried out for comparison purposes. The synthesized bionanosponge polyurethane materials were characterized using Fourier-transform infrared (FTIR) spectroscopy, Laser Raman spectroscopy, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) to give clear information regarding their structural, and dynamic physicochemical properties. The potency tests of the synthesized compounds were carried out against three bacterial strains Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and two fungal representatives Aspergillus ochraceus and Aspergillus fumigatus, using the disc diffusion method. Micro dilution and agar plating were used to determine the minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC), respectively. The results obtained revealed that pMWCNT-CD/Ag-TiO2 exhibits superior antibacterial and antifungal activities when compared to the other bionanosponge polymers tested. Thus, the bionanosponge polyurethane pMWCNT-CD/Ag-TiO2 nanocomposite can be considered as an active antimicrobial compound (AMC).

Original languageEnglish
Article number111092
JournalMaterials Science and Engineering C
Volume115
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Antimicrobial compound
  • Bionanosponge
  • Cyclodextrin
  • Minimum bactericidal concentration
  • Minimum fungicidal concentration
  • Polyurethane

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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