TY - JOUR
T1 - Spectroscopic characterization and antimicrobial activity of nanoparticle doped cyclodextrin polyurethane bionanosponge
AU - Leudjo Taka, Anny
AU - Doyle, Bryan P.
AU - Carleschi, Emanuela
AU - Youmbi Fonkui, Thierry
AU - Erasmus, Rudolph
AU - Fosso-Kankeu, Elvis
AU - Pillay, Kriveshini
AU - Mbianda, Xavier Y.
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/10
Y1 - 2020/10
N2 - This study reports on the spectroscopic characterization and antimicrobial potency of polyurethane cyclodextrin co-polymerized phosphorylated multiwalled carbon nanotube-doped Ag-TiO2 nanoparticle (pMWCNT-CD/Ag-TiO2) bionanosponge nanocomposite. The synthesis of pMWCNT-CD/Ag-TiO2 bionanosponge nanocomposite was carried out through the combined processes of amidation and polymerization reactions as well as the sol-gel method. The native nanosponge cyclodextrin and phosphorylated multiwalled carbon nanotube–nanosponge CD (pMWCNT-CD) polyurethanes were also prepared, and their antimicrobial activities carried out for comparison purposes. The synthesized bionanosponge polyurethane materials were characterized using Fourier-transform infrared (FTIR) spectroscopy, Laser Raman spectroscopy, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) to give clear information regarding their structural, and dynamic physicochemical properties. The potency tests of the synthesized compounds were carried out against three bacterial strains Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and two fungal representatives Aspergillus ochraceus and Aspergillus fumigatus, using the disc diffusion method. Micro dilution and agar plating were used to determine the minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC), respectively. The results obtained revealed that pMWCNT-CD/Ag-TiO2 exhibits superior antibacterial and antifungal activities when compared to the other bionanosponge polymers tested. Thus, the bionanosponge polyurethane pMWCNT-CD/Ag-TiO2 nanocomposite can be considered as an active antimicrobial compound (AMC).
AB - This study reports on the spectroscopic characterization and antimicrobial potency of polyurethane cyclodextrin co-polymerized phosphorylated multiwalled carbon nanotube-doped Ag-TiO2 nanoparticle (pMWCNT-CD/Ag-TiO2) bionanosponge nanocomposite. The synthesis of pMWCNT-CD/Ag-TiO2 bionanosponge nanocomposite was carried out through the combined processes of amidation and polymerization reactions as well as the sol-gel method. The native nanosponge cyclodextrin and phosphorylated multiwalled carbon nanotube–nanosponge CD (pMWCNT-CD) polyurethanes were also prepared, and their antimicrobial activities carried out for comparison purposes. The synthesized bionanosponge polyurethane materials were characterized using Fourier-transform infrared (FTIR) spectroscopy, Laser Raman spectroscopy, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) to give clear information regarding their structural, and dynamic physicochemical properties. The potency tests of the synthesized compounds were carried out against three bacterial strains Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and two fungal representatives Aspergillus ochraceus and Aspergillus fumigatus, using the disc diffusion method. Micro dilution and agar plating were used to determine the minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC), respectively. The results obtained revealed that pMWCNT-CD/Ag-TiO2 exhibits superior antibacterial and antifungal activities when compared to the other bionanosponge polymers tested. Thus, the bionanosponge polyurethane pMWCNT-CD/Ag-TiO2 nanocomposite can be considered as an active antimicrobial compound (AMC).
KW - Antimicrobial compound
KW - Bionanosponge
KW - Cyclodextrin
KW - Minimum bactericidal concentration
KW - Minimum fungicidal concentration
KW - Polyurethane
UR - http://www.scopus.com/inward/record.url?scp=85085637942&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2020.111092
DO - 10.1016/j.msec.2020.111092
M3 - Article
C2 - 32600696
AN - SCOPUS:85085637942
SN - 0928-4931
VL - 115
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
M1 - 111092
ER -