Solution-phase secondary-ion mass spectrometry of protonated amino acids

George R. Pettit; Gordon M. Cragg; Cedric W. Holzapfel; Albert A. Tuinman; Donald P. Gieschen

doi:10.1016/0003-2697(87)90032-7

Solution-phase secondary-ion mass spectrometry of protonated amino acids

George R. Pettit, Gordon M. Cragg, Cedric W. Holzapfel, Albert A. Tuinman, Donald P. Gieschen

Arizona State University

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Although sulfolane proved unexpectedly to be a poor solvent for solution-phase secondaryion mass spectrometry of underivatized amino acids in the presence of thallium(I) salts, glycerol was somewhat more effective. Also, the addition of trifluoromethanesulfonic acid proved more effective than addition of the metal in generating molecular ion complexes. A convenient and reliable method for rapidly determining amino acid molecular ions is based on these observations.

Original language	English
Pages (from-to)	236-241
Number of pages	6
Journal	Analytical Biochemistry
Volume	162
Issue number	1
DOIs	https://doi.org/10.1016/0003-2697(87)90032-7
Publication status	Published - Apr 1987
Externally published	Yes

Keywords

amino acids
mass spectrometry

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0003-2697(87)90032-7

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abstract = "Although sulfolane proved unexpectedly to be a poor solvent for solution-phase secondaryion mass spectrometry of underivatized amino acids in the presence of thallium(I) salts, glycerol was somewhat more effective. Also, the addition of trifluoromethanesulfonic acid proved more effective than addition of the metal in generating molecular ion complexes. A convenient and reliable method for rapidly determining amino acid molecular ions is based on these observations.",

keywords = "amino acids, mass spectrometry",

author = "Pettit, {George R.} and Cragg, {Gordon M.} and Holzapfel, {Cedric W.} and Tuinman, {Albert A.} and Gieschen, {Donald P.}",

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AU - Cragg, Gordon M.

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AU - Tuinman, Albert A.

AU - Gieschen, Donald P.

PY - 1987/4

Y1 - 1987/4

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AB - Although sulfolane proved unexpectedly to be a poor solvent for solution-phase secondaryion mass spectrometry of underivatized amino acids in the presence of thallium(I) salts, glycerol was somewhat more effective. Also, the addition of trifluoromethanesulfonic acid proved more effective than addition of the metal in generating molecular ion complexes. A convenient and reliable method for rapidly determining amino acid molecular ions is based on these observations.

KW - amino acids

KW - mass spectrometry

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ER -

Solution-phase secondary-ion mass spectrometry of protonated amino acids

Abstract

Keywords

ASJC Scopus subject areas

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