Solution-phase secondary-ion mass spectrometry of protonated amino acids

George R. Pettit, Gordon M. Cragg, Cedric W. Holzapfel, Albert A. Tuinman, Donald P. Gieschen

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Although sulfolane proved unexpectedly to be a poor solvent for solution-phase secondaryion mass spectrometry of underivatized amino acids in the presence of thallium(I) salts, glycerol was somewhat more effective. Also, the addition of trifluoromethanesulfonic acid proved more effective than addition of the metal in generating molecular ion complexes. A convenient and reliable method for rapidly determining amino acid molecular ions is based on these observations.

Original languageEnglish
Pages (from-to)236-241
Number of pages6
JournalAnalytical Biochemistry
Issue number1
Publication statusPublished - Apr 1987
Externally publishedYes


  • amino acids
  • mass spectrometry

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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