Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing

Sindi P. Ndlovu; Shirley C. M Motaung; Samson A. Adeyemi; Philemon Ubanako; Lindokuhle M. Ngema; Thierry Youmbi Fonkui; Derek Tantoh Ndinteh; Pradeep Kumar; Yahya E. Choonara; Blessing A. Aderibigbe

doi:10.1080/20415990.2024.2418800

Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing

Sindi P. Ndlovu, Shirley C. M Motaung, Samson A. Adeyemi, Philemon Ubanako, Lindokuhle M. Ngema, Thierry Youmbi Fonkui, Derek Tantoh Ndinteh, Pradeep Kumar, Yahya E. Choonara, Blessing A. Aderibigbe

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing. Materials & methods: Sodium alginate (SA)-based gels containing Carboxymethyl cellulose (CMC) and Pluronic F127 were prepared. The formulations. SA/CMC/Carbopol and SA/CMC/PluronicF127 were loaded with aqueous root extract of Capparis sepiaria. The formulations were characterized using appropriate techniques. Results: The gels' viscosity was in the range of 676.33 ± 121.76 to 20.00 ± 9.78 cP and in vitro whole blood kinetics showed their capability to induce a faster clotting rate. They also supported high cell viability of 80% with cellular migration and proliferation. Their antibacterial activity was significant against most bacteria strains used in the study. Conclusion: The gels' distinct features reveal their potential application as wound dressings for burn wounds.

Original language	English
Journal	Therapeutic Delivery
DOIs	https://doi.org/10.1080/20415990.2024.2418800
Publication status	Accepted/In press - 2024

Keywords

burn wounds
Capparis Sepiaria
sodium alginate
topical gels
wound dressings
wound healing

ASJC Scopus subject areas

Pharmaceutical Science

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10.1080/20415990.2024.2418800

Cite this

@article{8d552faf70bb45af96ccfac69c22c60a,

title = "Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing",

abstract = "Aim: Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing. Materials & methods: Sodium alginate (SA)-based gels containing Carboxymethyl cellulose (CMC) and Pluronic F127 were prepared. The formulations. SA/CMC/Carbopol and SA/CMC/PluronicF127 were loaded with aqueous root extract of Capparis sepiaria. The formulations were characterized using appropriate techniques. Results: The gels' viscosity was in the range of 676.33 ± 121.76 to 20.00 ± 9.78 cP and in vitro whole blood kinetics showed their capability to induce a faster clotting rate. They also supported high cell viability of 80% with cellular migration and proliferation. Their antibacterial activity was significant against most bacteria strains used in the study. Conclusion: The gels' distinct features reveal their potential application as wound dressings for burn wounds.",

keywords = "burn wounds, Capparis Sepiaria, sodium alginate, topical gels, wound dressings, wound healing",

author = "Ndlovu, {Sindi P.} and {M Motaung}, {Shirley C.} and Adeyemi, {Samson A.} and Philemon Ubanako and Ngema, {Lindokuhle M.} and Fonkui, {Thierry Youmbi} and Ndinteh, {Derek Tantoh} and Pradeep Kumar and Choonara, {Yahya E.} and Aderibigbe, {Blessing A.}",

note = "Publisher Copyright: {\textcopyright} 2024 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2024",

doi = "10.1080/20415990.2024.2418800",

language = "English",

journal = "Therapeutic Delivery",

issn = "2041-5990",

publisher = "Taylor and Francis Ltd.",

}

TY - JOUR

T1 - Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing

AU - Ndlovu, Sindi P.

AU - M Motaung, Shirley C.

AU - Adeyemi, Samson A.

AU - Ubanako, Philemon

AU - Ngema, Lindokuhle M.

AU - Fonkui, Thierry Youmbi

AU - Ndinteh, Derek Tantoh

AU - Kumar, Pradeep

AU - Choonara, Yahya E.

AU - Aderibigbe, Blessing A.

PY - 2024

Y1 - 2024

N2 - Aim: Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing. Materials & methods: Sodium alginate (SA)-based gels containing Carboxymethyl cellulose (CMC) and Pluronic F127 were prepared. The formulations. SA/CMC/Carbopol and SA/CMC/PluronicF127 were loaded with aqueous root extract of Capparis sepiaria. The formulations were characterized using appropriate techniques. Results: The gels' viscosity was in the range of 676.33 ± 121.76 to 20.00 ± 9.78 cP and in vitro whole blood kinetics showed their capability to induce a faster clotting rate. They also supported high cell viability of 80% with cellular migration and proliferation. Their antibacterial activity was significant against most bacteria strains used in the study. Conclusion: The gels' distinct features reveal their potential application as wound dressings for burn wounds.

AB - Aim: Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing. Materials & methods: Sodium alginate (SA)-based gels containing Carboxymethyl cellulose (CMC) and Pluronic F127 were prepared. The formulations. SA/CMC/Carbopol and SA/CMC/PluronicF127 were loaded with aqueous root extract of Capparis sepiaria. The formulations were characterized using appropriate techniques. Results: The gels' viscosity was in the range of 676.33 ± 121.76 to 20.00 ± 9.78 cP and in vitro whole blood kinetics showed their capability to induce a faster clotting rate. They also supported high cell viability of 80% with cellular migration and proliferation. Their antibacterial activity was significant against most bacteria strains used in the study. Conclusion: The gels' distinct features reveal their potential application as wound dressings for burn wounds.

KW - burn wounds

KW - Capparis Sepiaria

KW - sodium alginate

KW - topical gels

KW - wound dressings

KW - wound healing

UR - http://www.scopus.com/inward/record.url?scp=85209635325&partnerID=8YFLogxK

U2 - 10.1080/20415990.2024.2418800

DO - 10.1080/20415990.2024.2418800

M3 - Article

C2 - 39529611

AN - SCOPUS:85209635325

SN - 2041-5990

JO - Therapeutic Delivery

JF - Therapeutic Delivery

ER -

Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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