Sodium alginate stabilized silver nanoparticles–silica nanohybrid and their antibacterial characteristics

Sadanand Pandey, James Ramontja

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)


Due to the problem of resistance of many infectious agents to the usual treatments, this study addresses the ways of obtaining and using new sodium alginate stabilized-silver/mesoporous silica (Na-Alg-s-AgNPs@SiO2) nanohybrid as antimicrobial agents. Capping AgNPs with a shell of mesoporous SiO2 is a system to build the increase biocompatibility of AgNPs. In this work, we report a simple and green way to deal with setting up a uniform sodium alginate–stabilized silver nanoparticles embedded mesoporous silica (Na-Alg-s-AgNPs@SiO2 nanohybrid). The synthesized nanocomposite was characterized using transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectra, and ultraviolet-visible (UV–vis) absorption spectra, which exhibited that AgNPs with average of size of ∼7 nm were consistently and compactly deposited in the nanocomposite. The nanohybrid demonstrated excellent antibacterial activity against both Gram negative (−ve) and Gram positive (+ve) bacteria. Thus, the developed Na-Alg-s-AgNPs@SiO2 nanohybrid has a potential to be used for various antibacterial applications in biotechnology and biomedical fields.

Original languageEnglish
Pages (from-to)712-723
Number of pages12
JournalInternational Journal of Biological Macromolecules
Publication statusPublished - 1 Dec 2016


  • Antimicrobial activity
  • Bacteria
  • Biopolymer
  • Dispersity
  • Nanohybrid
  • Silver nanoparticles

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • General Energy


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