Sodium alginate passivated CuInS2/ZnS QDs encapsulated in the mesoporous channels of amine modified SBA 15 with excellent photostability and biocompatibility

R. Jose Varghese; Sundararajan Parani; V. R. Remya; Rodney Maluleke; Sabu Thomas; Oluwatobi S. Oluwafemi

doi:10.1016/j.ijbiomac.2020.07.240

Sodium alginate passivated CuInS₂/ZnS QDs encapsulated in the mesoporous channels of amine modified SBA 15 with excellent photostability and biocompatibility

R. Jose Varghese, Sundararajan Parani, V. R. Remya, Rodney Maluleke, Sabu Thomas, Oluwatobi S. Oluwafemi

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

We herein report the synthesis of CuInS₂/ZnS (CIS/ZnS) quantum dots (QDs) via a greener method followed by sodium alginate (SA) passivation and encapsulation into mesoporous channels of amine modified silica (SBA15-NH₂) for improved photostability and biocompatibility. The as-synthesized CIS/ZnS QDs exhibited near infrared emission even after SA passivation and silica encapsulation. Transmission electron microscopy (TEM) and Small angle X-ray diffraction (XRD) revealed the mesoporous nature of the SBA-15 remained stable after loading with the SA-CIS/ZnS QDs. The effective encapsulation of SA-CIS/ZnS QDs inside the pores of SBA15-NH₂ matrix was confirmed by Brunauer-Emmett-Teller (BET) pore volume analysis while the interaction between the QDs and SBA15-NH₂ was confirmed using Fourier transform infrared (FTIR) spectroscopy. The photostability of the QDs was greatly enhanced after these modifications. The resultant SA-CIS/ZnS-SBA15-NH₂ (QDs-silica) composite possessed remarkable biocompatibility towards lung cancer (A549) and kidney (HEK 293) cell lines making it a versatile material for theranostic applications.

Original language	English
Pages (from-to)	1470-1474
Number of pages	5
Journal	International Journal of Biological Macromolecules
Volume	161
DOIs	https://doi.org/10.1016/j.ijbiomac.2020.07.240
Publication status	Published - 15 Oct 2020

Keywords

Cell viability
Mesoporous silica
Photostability
Quantum dots
Sodium alginate

ASJC Scopus subject areas

Structural Biology
Biochemistry
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ijbiomac.2020.07.240

Cite this

Jose Varghese, R., Parani, S., Remya, V. R., Maluleke, R., Thomas, S., & Oluwafemi, O. S. (2020). Sodium alginate passivated CuInS₂/ZnS QDs encapsulated in the mesoporous channels of amine modified SBA 15 with excellent photostability and biocompatibility. International Journal of Biological Macromolecules, 161, 1470-1474. https://doi.org/10.1016/j.ijbiomac.2020.07.240

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title = "Sodium alginate passivated CuInS2/ZnS QDs encapsulated in the mesoporous channels of amine modified SBA 15 with excellent photostability and biocompatibility",

abstract = "We herein report the synthesis of CuInS2/ZnS (CIS/ZnS) quantum dots (QDs) via a greener method followed by sodium alginate (SA) passivation and encapsulation into mesoporous channels of amine modified silica (SBA15-NH2) for improved photostability and biocompatibility. The as-synthesized CIS/ZnS QDs exhibited near infrared emission even after SA passivation and silica encapsulation. Transmission electron microscopy (TEM) and Small angle X-ray diffraction (XRD) revealed the mesoporous nature of the SBA-15 remained stable after loading with the SA-CIS/ZnS QDs. The effective encapsulation of SA-CIS/ZnS QDs inside the pores of SBA15-NH2 matrix was confirmed by Brunauer-Emmett-Teller (BET) pore volume analysis while the interaction between the QDs and SBA15-NH2 was confirmed using Fourier transform infrared (FTIR) spectroscopy. The photostability of the QDs was greatly enhanced after these modifications. The resultant SA-CIS/ZnS-SBA15-NH2 (QDs-silica) composite possessed remarkable biocompatibility towards lung cancer (A549) and kidney (HEK 293) cell lines making it a versatile material for theranostic applications.",

keywords = "Cell viability, Mesoporous silica, Photostability, Quantum dots, Sodium alginate",

author = "{Jose Varghese}, R. and Sundararajan Parani and Remya, {V. R.} and Rodney Maluleke and Sabu Thomas and Oluwafemi, {Oluwatobi S.}",

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doi = "10.1016/j.ijbiomac.2020.07.240",

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Sodium alginate passivated CuInS₂/ZnS QDs encapsulated in the mesoporous channels of amine modified SBA 15 with excellent photostability and biocompatibility. / Jose Varghese, R.; Parani, Sundararajan; Remya, V. R. et al.
In: International Journal of Biological Macromolecules, Vol. 161, 15.10.2020, p. 1470-1474.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Sodium alginate passivated CuInS2/ZnS QDs encapsulated in the mesoporous channels of amine modified SBA 15 with excellent photostability and biocompatibility

AU - Jose Varghese, R.

AU - Parani, Sundararajan

AU - Remya, V. R.

AU - Maluleke, Rodney

AU - Thomas, Sabu

AU - Oluwafemi, Oluwatobi S.

PY - 2020/10/15

Y1 - 2020/10/15

N2 - We herein report the synthesis of CuInS2/ZnS (CIS/ZnS) quantum dots (QDs) via a greener method followed by sodium alginate (SA) passivation and encapsulation into mesoporous channels of amine modified silica (SBA15-NH2) for improved photostability and biocompatibility. The as-synthesized CIS/ZnS QDs exhibited near infrared emission even after SA passivation and silica encapsulation. Transmission electron microscopy (TEM) and Small angle X-ray diffraction (XRD) revealed the mesoporous nature of the SBA-15 remained stable after loading with the SA-CIS/ZnS QDs. The effective encapsulation of SA-CIS/ZnS QDs inside the pores of SBA15-NH2 matrix was confirmed by Brunauer-Emmett-Teller (BET) pore volume analysis while the interaction between the QDs and SBA15-NH2 was confirmed using Fourier transform infrared (FTIR) spectroscopy. The photostability of the QDs was greatly enhanced after these modifications. The resultant SA-CIS/ZnS-SBA15-NH2 (QDs-silica) composite possessed remarkable biocompatibility towards lung cancer (A549) and kidney (HEK 293) cell lines making it a versatile material for theranostic applications.

AB - We herein report the synthesis of CuInS2/ZnS (CIS/ZnS) quantum dots (QDs) via a greener method followed by sodium alginate (SA) passivation and encapsulation into mesoporous channels of amine modified silica (SBA15-NH2) for improved photostability and biocompatibility. The as-synthesized CIS/ZnS QDs exhibited near infrared emission even after SA passivation and silica encapsulation. Transmission electron microscopy (TEM) and Small angle X-ray diffraction (XRD) revealed the mesoporous nature of the SBA-15 remained stable after loading with the SA-CIS/ZnS QDs. The effective encapsulation of SA-CIS/ZnS QDs inside the pores of SBA15-NH2 matrix was confirmed by Brunauer-Emmett-Teller (BET) pore volume analysis while the interaction between the QDs and SBA15-NH2 was confirmed using Fourier transform infrared (FTIR) spectroscopy. The photostability of the QDs was greatly enhanced after these modifications. The resultant SA-CIS/ZnS-SBA15-NH2 (QDs-silica) composite possessed remarkable biocompatibility towards lung cancer (A549) and kidney (HEK 293) cell lines making it a versatile material for theranostic applications.

KW - Cell viability

KW - Mesoporous silica

KW - Photostability

KW - Quantum dots

KW - Sodium alginate

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JF - International Journal of Biological Macromolecules

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