Smart mesoporous silica nanoparticles for controlled-release drug delivery

Mahdi Karimi, Hamed Mirshekari, Masoumeh Aliakbari, Parham Sahandi-Zangabad, Michael R. Hamblin

Research output: Contribution to journalReview articlepeer-review

80 Citations (Scopus)


Stimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular "gatekeepers" or "nanovalves." In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH, while external stimuli include light, ultrasound, and magnetic fields, and temperature can either be internal or external.

Original languageEnglish
Pages (from-to)195-207
Number of pages13
JournalNanotechnology Reviews
Issue number2
Publication statusPublished - 1 Apr 2016
Externally publishedYes


  • drug delivery systems
  • enzyme
  • light-responsive nanocarriers
  • magnetic
  • mesoporous silica nanoparticles
  • pH
  • redox
  • stimuli responsive
  • temperature

ASJC Scopus subject areas

  • Biotechnology
  • Medicine (miscellaneous)
  • Materials Science (miscellaneous)
  • Energy Engineering and Power Technology
  • Engineering (miscellaneous)
  • Process Chemistry and Technology


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