Abstract
Singlet oxygen is a dominant reactive oxygen species that determine the fate of photodynamic therapy efficacy. We herein report the singlet oxygen generation potential of a newly synthesized superparamagnetic iron oxide nanoparticles-gold core-shell porphyrin conjugate prepared for the purpose of achieving magnetically-driven porphyrin structure. Successful conjugation was achieved via encapsulation within thiolated methoxy polyethylene glycol matrix following solvent evaporation approach. The magnetic PEGylated porphyrin nano-construct was characterized using optical absorption, transmission electron microscopy (TEM) and zeta potential techniques. The as-synthesized porphyrin conjugate emits red and near-infrared light at various excitations from ultraviolet to visible, shows strong attraction towards external magnetic field and exhibits high singlet oxygen generation potential.
| Original language | English |
|---|---|
| Pages (from-to) | 37-40 |
| Number of pages | 4 |
| Journal | Materials Letters |
| Volume | 199 |
| DOIs | |
| Publication status | Published - 15 Jul 2017 |
Keywords
- Gold
- Photodynamic therapy
- Photosensitizer
- Porphyrin
- SPIONs
- Singlet oxygen
ASJC Scopus subject areas
- General Materials Science
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering