Singlet oxygen generation potential of thiolated methoxy-polyethyleneglycol encapsulated superparamagnetic iron oxide nanoparticles-gold core-shell meso-5, 10, 15, 20-tetrakis (4-hydroxyphenyl) porphyrin

Olayemi J. Fakayode; Sandile P. Songca; Oluwatobi S. Oluwafemi

doi:10.1016/j.matlet.2017.04.045

Singlet oxygen generation potential of thiolated methoxy-polyethyleneglycol encapsulated superparamagnetic iron oxide nanoparticles-gold core-shell meso-5, 10, 15, 20-tetrakis (4-hydroxyphenyl) porphyrin

Olayemi J. Fakayode, Sandile P. Songca, Oluwatobi S. Oluwafemi

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Singlet oxygen is a dominant reactive oxygen species that determine the fate of photodynamic therapy efficacy. We herein report the singlet oxygen generation potential of a newly synthesized superparamagnetic iron oxide nanoparticles-gold core-shell porphyrin conjugate prepared for the purpose of achieving magnetically-driven porphyrin structure. Successful conjugation was achieved via encapsulation within thiolated methoxy polyethylene glycol matrix following solvent evaporation approach. The magnetic PEGylated porphyrin nano-construct was characterized using optical absorption, transmission electron microscopy (TEM) and zeta potential techniques. The as-synthesized porphyrin conjugate emits red and near-infrared light at various excitations from ultraviolet to visible, shows strong attraction towards external magnetic field and exhibits high singlet oxygen generation potential.

Original language	English
Pages (from-to)	37-40
Number of pages	4
Journal	Materials Letters
Volume	199
DOIs	https://doi.org/10.1016/j.matlet.2017.04.045
Publication status	Published - 15 Jul 2017

Keywords

Gold
Photodynamic therapy
Photosensitizer
Porphyrin
SPIONs
Singlet oxygen

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/j.matlet.2017.04.045

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title = "Singlet oxygen generation potential of thiolated methoxy-polyethyleneglycol encapsulated superparamagnetic iron oxide nanoparticles-gold core-shell meso-5, 10, 15, 20-tetrakis (4-hydroxyphenyl) porphyrin",

abstract = "Singlet oxygen is a dominant reactive oxygen species that determine the fate of photodynamic therapy efficacy. We herein report the singlet oxygen generation potential of a newly synthesized superparamagnetic iron oxide nanoparticles-gold core-shell porphyrin conjugate prepared for the purpose of achieving magnetically-driven porphyrin structure. Successful conjugation was achieved via encapsulation within thiolated methoxy polyethylene glycol matrix following solvent evaporation approach. The magnetic PEGylated porphyrin nano-construct was characterized using optical absorption, transmission electron microscopy (TEM) and zeta potential techniques. The as-synthesized porphyrin conjugate emits red and near-infrared light at various excitations from ultraviolet to visible, shows strong attraction towards external magnetic field and exhibits high singlet oxygen generation potential.",

keywords = "Gold, Photodynamic therapy, Photosensitizer, Porphyrin, SPIONs, Singlet oxygen",

author = "Fakayode, {Olayemi J.} and Songca, {Sandile P.} and Oluwafemi, {Oluwatobi S.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

month = jul,

day = "15",

doi = "10.1016/j.matlet.2017.04.045",

language = "English",

volume = "199",

pages = "37--40",

journal = "Materials Letters",

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Singlet oxygen generation potential of thiolated methoxy-polyethyleneglycol encapsulated superparamagnetic iron oxide nanoparticles-gold core-shell meso-5, 10, 15, 20-tetrakis (4-hydroxyphenyl) porphyrin. / Fakayode, Olayemi J.; Songca, Sandile P.; Oluwafemi, Oluwatobi S.
In: Materials Letters, Vol. 199, 15.07.2017, p. 37-40.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Singlet oxygen generation potential of thiolated methoxy-polyethyleneglycol encapsulated superparamagnetic iron oxide nanoparticles-gold core-shell meso-5, 10, 15, 20-tetrakis (4-hydroxyphenyl) porphyrin

AU - Fakayode, Olayemi J.

AU - Songca, Sandile P.

AU - Oluwafemi, Oluwatobi S.

PY - 2017/7/15

Y1 - 2017/7/15

N2 - Singlet oxygen is a dominant reactive oxygen species that determine the fate of photodynamic therapy efficacy. We herein report the singlet oxygen generation potential of a newly synthesized superparamagnetic iron oxide nanoparticles-gold core-shell porphyrin conjugate prepared for the purpose of achieving magnetically-driven porphyrin structure. Successful conjugation was achieved via encapsulation within thiolated methoxy polyethylene glycol matrix following solvent evaporation approach. The magnetic PEGylated porphyrin nano-construct was characterized using optical absorption, transmission electron microscopy (TEM) and zeta potential techniques. The as-synthesized porphyrin conjugate emits red and near-infrared light at various excitations from ultraviolet to visible, shows strong attraction towards external magnetic field and exhibits high singlet oxygen generation potential.

AB - Singlet oxygen is a dominant reactive oxygen species that determine the fate of photodynamic therapy efficacy. We herein report the singlet oxygen generation potential of a newly synthesized superparamagnetic iron oxide nanoparticles-gold core-shell porphyrin conjugate prepared for the purpose of achieving magnetically-driven porphyrin structure. Successful conjugation was achieved via encapsulation within thiolated methoxy polyethylene glycol matrix following solvent evaporation approach. The magnetic PEGylated porphyrin nano-construct was characterized using optical absorption, transmission electron microscopy (TEM) and zeta potential techniques. The as-synthesized porphyrin conjugate emits red and near-infrared light at various excitations from ultraviolet to visible, shows strong attraction towards external magnetic field and exhibits high singlet oxygen generation potential.

KW - Gold

KW - Photodynamic therapy

KW - Photosensitizer

KW - Porphyrin

KW - SPIONs

KW - Singlet oxygen

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U2 - 10.1016/j.matlet.2017.04.045

DO - 10.1016/j.matlet.2017.04.045

M3 - Article

AN - SCOPUS:85017471110

SN - 0167-577X

VL - 199

SP - 37

EP - 40

JO - Materials Letters

JF - Materials Letters

ER -

Singlet oxygen generation potential of thiolated methoxy-polyethyleneglycol encapsulated superparamagnetic iron oxide nanoparticles-gold core-shell meso-5, 10, 15, 20-tetrakis (4-hydroxyphenyl) porphyrin

Abstract

Keywords

ASJC Scopus subject areas

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