ROS, Cancer, Stem Cells

Cellular oxidation-reduction (redox) status plays a vital role in the physiological and functional activities of a living cell. Redox status is manifested as the balance in the cellular antioxidant mechanisms of oxidized/reduced these free radicals. Often, minor variations in this redox balance brings beneficial effects to sustenance and growth of healthy cells, whereas, a higher imbalance of it alters homeostasis leading to cancer. Such situations can lead to changes in cellular signaling and metabolic pathways and perhaps, these changes are a manifestation of the cellular “redox signature.” In fact, several anticancer agents possess anti-/pro-oxidants properties capable of manipulating this “redox signature” and bringing desirable effects. Here, we analyze the cellular effects of various anticancer compounds in relation to the anti-/pro-oxidants properties. Perhaps, the pathological conditions of a cell are an outcome of changes in the relative proportion of beneficial and harmful ROS. A good understanding of their interactions in normal and diseased cells may help us to adopt proper control and treatment measures.