Roles of Non-coding RNAs and Angiogenesis in Glioblastoma

Ebrahim Balandeh; Kimia Mohammadshafie; Yaser Mahmoudi; Mohammad Hossein Pourhanifeh; Ali Rajabi; Zahra Razaghi Bahabadi; Amir Hossein Mohammadi; Neda Rahimian; Michael R. Hamblin; Hamed Mirzaei

doi:10.3389/fcell.2021.716462

Roles of Non-coding RNAs and Angiogenesis in Glioblastoma

Ebrahim Balandeh, Kimia Mohammadshafie, Yaser Mahmoudi, Mohammad Hossein Pourhanifeh, Ali Rajabi, Zahra Razaghi Bahabadi, Amir Hossein Mohammadi, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei

Laser Research Centre

Research output: Contribution to journal › Review article › peer-review

49 Citations (Scopus)

Abstract

One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (GBM) of non-coding RNAs (ncRNAs), including long ncRNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). These ncRNAs may function in trans or cis forms and modify gene transcription by various mechanisms, including epigenetics. NcRNAs may also serve as crucial regulators of angiogenesis-inducing molecules. These molecules include, metalloproteinases, cytokines, several growth factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblast growth factor, hypoxia-inducible factor-1, and epidermal growth factor), phosphoinositide 3-kinase, mitogen-activated protein kinase, and transforming growth factor signaling pathways.

Original language	English
Article number	716462
Journal	Frontiers in Cell and Developmental Biology
Volume	9
DOIs	https://doi.org/10.3389/fcell.2021.716462
Publication status	Published - 27 Sept 2021

Keywords

angiogenesis
exosomes
glioblastoma
long non-coding RNAs
microRNAs
non-coding RNAs

ASJC Scopus subject areas

Developmental Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fcell.2021.716462

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@article{57310900b73449208c343ffceb556270,

title = "Roles of Non-coding RNAs and Angiogenesis in Glioblastoma",

abstract = "One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (GBM) of non-coding RNAs (ncRNAs), including long ncRNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). These ncRNAs may function in trans or cis forms and modify gene transcription by various mechanisms, including epigenetics. NcRNAs may also serve as crucial regulators of angiogenesis-inducing molecules. These molecules include, metalloproteinases, cytokines, several growth factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblast growth factor, hypoxia-inducible factor-1, and epidermal growth factor), phosphoinositide 3-kinase, mitogen-activated protein kinase, and transforming growth factor signaling pathways.",

keywords = "angiogenesis, exosomes, glioblastoma, long non-coding RNAs, microRNAs, non-coding RNAs",

author = "Ebrahim Balandeh and Kimia Mohammadshafie and Yaser Mahmoudi and {Hossein Pourhanifeh}, Mohammad and Ali Rajabi and Bahabadi, {Zahra Razaghi} and Mohammadi, {Amir Hossein} and Neda Rahimian and Hamblin, {Michael R.} and Hamed Mirzaei",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Balandeh, Mohammadshafie, Mahmoudi, Hossein Pourhanifeh, Rajabi, Bahabadi, Mohammadi, Rahimian, Hamblin and Mirzaei.",

year = "2021",

month = sep,

day = "27",

doi = "10.3389/fcell.2021.716462",

language = "English",

volume = "9",

journal = "Frontiers in Cell and Developmental Biology",

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T1 - Roles of Non-coding RNAs and Angiogenesis in Glioblastoma

AU - Balandeh, Ebrahim

AU - Mohammadshafie, Kimia

AU - Mahmoudi, Yaser

AU - Hossein Pourhanifeh, Mohammad

AU - Rajabi, Ali

AU - Bahabadi, Zahra Razaghi

AU - Mohammadi, Amir Hossein

AU - Rahimian, Neda

AU - Hamblin, Michael R.

AU - Mirzaei, Hamed

PY - 2021/9/27

Y1 - 2021/9/27

N2 - One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (GBM) of non-coding RNAs (ncRNAs), including long ncRNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). These ncRNAs may function in trans or cis forms and modify gene transcription by various mechanisms, including epigenetics. NcRNAs may also serve as crucial regulators of angiogenesis-inducing molecules. These molecules include, metalloproteinases, cytokines, several growth factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblast growth factor, hypoxia-inducible factor-1, and epidermal growth factor), phosphoinositide 3-kinase, mitogen-activated protein kinase, and transforming growth factor signaling pathways.

AB - One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (GBM) of non-coding RNAs (ncRNAs), including long ncRNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). These ncRNAs may function in trans or cis forms and modify gene transcription by various mechanisms, including epigenetics. NcRNAs may also serve as crucial regulators of angiogenesis-inducing molecules. These molecules include, metalloproteinases, cytokines, several growth factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblast growth factor, hypoxia-inducible factor-1, and epidermal growth factor), phosphoinositide 3-kinase, mitogen-activated protein kinase, and transforming growth factor signaling pathways.

KW - angiogenesis

KW - exosomes

KW - glioblastoma

KW - long non-coding RNAs

KW - microRNAs

KW - non-coding RNAs

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U2 - 10.3389/fcell.2021.716462

DO - 10.3389/fcell.2021.716462

M3 - Review article

AN - SCOPUS:85116872784

SN - 2296-634X

VL - 9

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

M1 - 716462

ER -

Roles of Non-coding RNAs and Angiogenesis in Glioblastoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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