Roles of Non-coding RNAs and Angiogenesis in Glioblastoma

Ebrahim Balandeh, Kimia Mohammadshafie, Yaser Mahmoudi, Mohammad Hossein Pourhanifeh, Ali Rajabi, Zahra Razaghi Bahabadi, Amir Hossein Mohammadi, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)


One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (GBM) of non-coding RNAs (ncRNAs), including long ncRNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). These ncRNAs may function in trans or cis forms and modify gene transcription by various mechanisms, including epigenetics. NcRNAs may also serve as crucial regulators of angiogenesis-inducing molecules. These molecules include, metalloproteinases, cytokines, several growth factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblast growth factor, hypoxia-inducible factor-1, and epidermal growth factor), phosphoinositide 3-kinase, mitogen-activated protein kinase, and transforming growth factor signaling pathways.

Original languageEnglish
Article number716462
JournalFrontiers in Cell and Developmental Biology
Publication statusPublished - 27 Sept 2021


  • angiogenesis
  • exosomes
  • glioblastoma
  • long non-coding RNAs
  • microRNAs
  • non-coding RNAs

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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