Roles of heat shock proteins in apoptosis, oxidative stress, human inflammatory diseases, and cancer

Paul Chukwudi Ikwegbue, Priscilla Masamba, Babatunji Emmanuel Oyinloye, Abidemi Paul Kappo

Research output: Contribution to journalReview articlepeer-review

196 Citations (Scopus)

Abstract

Heat shock proteins (HSPs) play cytoprotective activities under pathological conditions through the initiation of protein folding, repair, refolding of misfolded peptides, and possible degradation of irreparable proteins. Excessive apoptosis, resulting from increased reactive oxygen species (ROS) cellular levels and subsequent amplified inflammatory reactions, is well known in the pathogenesis and progression of several human inflammatory diseases (HIDs) and cancer. Under normal physiological conditions, ROS levels and inflammatory reactions are kept in check for the cellular benefits of fighting off infectious agents through antioxidant mechanisms; however, this balance can be disrupted under pathological conditions, thus leading to oxidative stress and massive cellular destruction. Therefore, it becomes apparent that the interplay between oxidant-apoptosis-inflammation is critical in the dysfunction of the antioxidant system and, most importantly, in the progression of HIDs. Hence, there is a need to maintain careful balance between the oxidant-antioxidant inflammatory status in the human body. HSPs are known to modulate the effects of inflammation cascades leading to the endogenous generation of ROS and intrinsic apoptosis through inhibition of pro-inflammatory factors, thereby playing crucial roles in the pathogenesis of HIDs and cancer. We propose that careful induction of HSPs in HIDs and cancer, especially prior to inflammation, will provide good therapeutics in the management and treatment of HIDs and cancer.

Original languageEnglish
Article number2
JournalPharmaceuticals
Volume11
Issue number1
DOIs
Publication statusPublished - Mar 2018
Externally publishedYes

Keywords

  • Apoptosis
  • Cancer
  • Heat shock proteins
  • Inflammation
  • Reactive oxygen species
  • Tumour necrosis factor-α

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

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