Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment

Nasim Ebrahimi; Kamyar Kharazmi; Masoud Ghanaatian; Seyed Ali Miraghel; Yasaman Amiri; Seyede Sanaz Seyedebrahimi; Halimeh Mobarak; Elnaz Yazdani; Sahar Parkhideh; Michael R. Hamblin; Amir Reza Aref

doi:10.1016/j.cytogfr.2022.05.001

Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment

Nasim Ebrahimi, Kamyar Kharazmi, Masoud Ghanaatian, Seyed Ali Miraghel, Yasaman Amiri, Seyede Sanaz Seyedebrahimi, Halimeh Mobarak, Elnaz Yazdani, Sahar Parkhideh, Michael R. Hamblin, Amir Reza Aref

Laser Research Centre

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Breast cancer (BC) is the most frequently diagnosed cancer among women in all the populations of the world. Although the BC mortality rate has declined, resistance to treatment is still a significant challenge for patient survival. Various cellular signaling pathways, such as Wnt and Rho/GTPase have been linked to the development, migration, and metastasis of BC, and also in treatment resistance mechanisms. Some studies have shown an association between two important cellular pathways, Wnt and Rho/GTPase, in cytoskeleton activation and cancer invasion. However, their involvement in BC has received little attention. This review summarizes the Wnt and Rho/GTPases signaling pathway functions, and also the crosstalk between these pathways in the progression, metastasis, and drug resistance mechanisms in BC. Considering the signaling pathways involved in BC tumorigenesis, future studies will need to investigate possible molecular interventions and new opportunities for the development of personalized strategies for BC treatment in order to improve overall outcomes.

Original language	English
Pages (from-to)	11-24
Number of pages	14
Journal	Cytokine and Growth Factor Reviews
Volume	67
DOIs	https://doi.org/10.1016/j.cytogfr.2022.05.001
Publication status	Published - Oct 2022

Keywords

Breast cancer
Resistance to treatment
Rho/GTPase proteins
Wnt signaling pathway

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cytogfr.2022.05.001

Cite this

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title = "Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment",

abstract = "Breast cancer (BC) is the most frequently diagnosed cancer among women in all the populations of the world. Although the BC mortality rate has declined, resistance to treatment is still a significant challenge for patient survival. Various cellular signaling pathways, such as Wnt and Rho/GTPase have been linked to the development, migration, and metastasis of BC, and also in treatment resistance mechanisms. Some studies have shown an association between two important cellular pathways, Wnt and Rho/GTPase, in cytoskeleton activation and cancer invasion. However, their involvement in BC has received little attention. This review summarizes the Wnt and Rho/GTPases signaling pathway functions, and also the crosstalk between these pathways in the progression, metastasis, and drug resistance mechanisms in BC. Considering the signaling pathways involved in BC tumorigenesis, future studies will need to investigate possible molecular interventions and new opportunities for the development of personalized strategies for BC treatment in order to improve overall outcomes.",

keywords = "Breast cancer, Resistance to treatment, Rho/GTPase proteins, Wnt signaling pathway",

author = "Nasim Ebrahimi and Kamyar Kharazmi and Masoud Ghanaatian and Miraghel, \{Seyed Ali\} and Yasaman Amiri and Seyedebrahimi, \{Seyede Sanaz\} and Halimeh Mobarak and Elnaz Yazdani and Sahar Parkhideh and Hamblin, \{Michael R.\} and Aref, \{Amir Reza\}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = oct,

doi = "10.1016/j.cytogfr.2022.05.001",

language = "English",

volume = "67",

pages = "11--24",

journal = "Cytokine and Growth Factor Reviews",

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TY - JOUR

T1 - Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment

AU - Ebrahimi, Nasim

AU - Kharazmi, Kamyar

AU - Ghanaatian, Masoud

AU - Miraghel, Seyed Ali

AU - Amiri, Yasaman

AU - Seyedebrahimi, Seyede Sanaz

AU - Mobarak, Halimeh

AU - Yazdani, Elnaz

AU - Parkhideh, Sahar

AU - Hamblin, Michael R.

AU - Aref, Amir Reza

PY - 2022/10

Y1 - 2022/10

N2 - Breast cancer (BC) is the most frequently diagnosed cancer among women in all the populations of the world. Although the BC mortality rate has declined, resistance to treatment is still a significant challenge for patient survival. Various cellular signaling pathways, such as Wnt and Rho/GTPase have been linked to the development, migration, and metastasis of BC, and also in treatment resistance mechanisms. Some studies have shown an association between two important cellular pathways, Wnt and Rho/GTPase, in cytoskeleton activation and cancer invasion. However, their involvement in BC has received little attention. This review summarizes the Wnt and Rho/GTPases signaling pathway functions, and also the crosstalk between these pathways in the progression, metastasis, and drug resistance mechanisms in BC. Considering the signaling pathways involved in BC tumorigenesis, future studies will need to investigate possible molecular interventions and new opportunities for the development of personalized strategies for BC treatment in order to improve overall outcomes.

AB - Breast cancer (BC) is the most frequently diagnosed cancer among women in all the populations of the world. Although the BC mortality rate has declined, resistance to treatment is still a significant challenge for patient survival. Various cellular signaling pathways, such as Wnt and Rho/GTPase have been linked to the development, migration, and metastasis of BC, and also in treatment resistance mechanisms. Some studies have shown an association between two important cellular pathways, Wnt and Rho/GTPase, in cytoskeleton activation and cancer invasion. However, their involvement in BC has received little attention. This review summarizes the Wnt and Rho/GTPases signaling pathway functions, and also the crosstalk between these pathways in the progression, metastasis, and drug resistance mechanisms in BC. Considering the signaling pathways involved in BC tumorigenesis, future studies will need to investigate possible molecular interventions and new opportunities for the development of personalized strategies for BC treatment in order to improve overall outcomes.

KW - Breast cancer

KW - Resistance to treatment

KW - Rho/GTPase proteins

KW - Wnt signaling pathway

UR - https://www.scopus.com/pages/publications/85135540129

U2 - 10.1016/j.cytogfr.2022.05.001

DO - 10.1016/j.cytogfr.2022.05.001

M3 - Review article

C2 - 35934612

AN - SCOPUS:85135540129

SN - 1359-6101

VL - 67

SP - 11

EP - 24

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

ER -

Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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