TY - JOUR
T1 - Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment
AU - Ebrahimi, Nasim
AU - Kharazmi, Kamyar
AU - Ghanaatian, Masoud
AU - Miraghel, Seyed Ali
AU - Amiri, Yasaman
AU - Seyedebrahimi, Seyede Sanaz
AU - Mobarak, Halimeh
AU - Yazdani, Elnaz
AU - Parkhideh, Sahar
AU - Hamblin, Michael R.
AU - Aref, Amir Reza
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/10
Y1 - 2022/10
N2 - Breast cancer (BC) is the most frequently diagnosed cancer among women in all the populations of the world. Although the BC mortality rate has declined, resistance to treatment is still a significant challenge for patient survival. Various cellular signaling pathways, such as Wnt and Rho/GTPase have been linked to the development, migration, and metastasis of BC, and also in treatment resistance mechanisms. Some studies have shown an association between two important cellular pathways, Wnt and Rho/GTPase, in cytoskeleton activation and cancer invasion. However, their involvement in BC has received little attention. This review summarizes the Wnt and Rho/GTPases signaling pathway functions, and also the crosstalk between these pathways in the progression, metastasis, and drug resistance mechanisms in BC. Considering the signaling pathways involved in BC tumorigenesis, future studies will need to investigate possible molecular interventions and new opportunities for the development of personalized strategies for BC treatment in order to improve overall outcomes.
AB - Breast cancer (BC) is the most frequently diagnosed cancer among women in all the populations of the world. Although the BC mortality rate has declined, resistance to treatment is still a significant challenge for patient survival. Various cellular signaling pathways, such as Wnt and Rho/GTPase have been linked to the development, migration, and metastasis of BC, and also in treatment resistance mechanisms. Some studies have shown an association between two important cellular pathways, Wnt and Rho/GTPase, in cytoskeleton activation and cancer invasion. However, their involvement in BC has received little attention. This review summarizes the Wnt and Rho/GTPases signaling pathway functions, and also the crosstalk between these pathways in the progression, metastasis, and drug resistance mechanisms in BC. Considering the signaling pathways involved in BC tumorigenesis, future studies will need to investigate possible molecular interventions and new opportunities for the development of personalized strategies for BC treatment in order to improve overall outcomes.
KW - Breast cancer
KW - Resistance to treatment
KW - Rho/GTPase proteins
KW - Wnt signaling pathway
UR - http://www.scopus.com/inward/record.url?scp=85135540129&partnerID=8YFLogxK
U2 - 10.1016/j.cytogfr.2022.05.001
DO - 10.1016/j.cytogfr.2022.05.001
M3 - Review article
C2 - 35934612
AN - SCOPUS:85135540129
SN - 1359-6101
VL - 67
SP - 11
EP - 24
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
ER -
