Role of the PI3K/AKT (mTOR and GSK3β) signalling pathway and photobiomodulation in diabetic wound healing

Sandy W. Jere; Nicolette N. Houreld; Heidi Abrahamse

doi:10.1016/j.cytogfr.2019.03.001

Role of the PI3K/AKT (mTOR and GSK3β) signalling pathway and photobiomodulation in diabetic wound healing

Sandy W. Jere, Nicolette N. Houreld, Heidi Abrahamse

Laser Research Centre

University of Johannesburg

Research output: Contribution to journal › Short survey › peer-review

123 Citations (Scopus)

Abstract

Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3β activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance. The occurrence of diabetic ulcers is linked to peripheral arterial disease, neuropathy, and wound contamination. Lasers or light emitting diodes (LEDs) provide photon energy with therapeutic benefits (Photobiomodulation-PBM), and has been broadly commended to quicken diabetic wound healing. PBM is efficient in the visible red and near-infrared electromagnetic spectrum, and fluencies ranging from 2 to 6 J/cm². However, cellular and molecular mechanisms induced by PBM are not fully understood. In this review we discuss PBM and the PI3K/AKT pathway with specific focus on the mTOR and GSK3β downstream activity in diabetic wound healing.

Original language	English
Pages (from-to)	52-59
Number of pages	8
Journal	Cytokine and Growth Factor Reviews
Volume	50
DOIs	https://doi.org/10.1016/j.cytogfr.2019.03.001
Publication status	Published - Dec 2019

Keywords

AKT
Bcl2
Diabetes mellitus
Diabetic ulcers
GSK3
Growth factors
PI3K
Photobiomodulation
TOR
Wound healing

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cytogfr.2019.03.001

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@article{98f14b1674604d54ae8963a5ee9e6d99,

title = "Role of the PI3K/AKT (mTOR and GSK3β) signalling pathway and photobiomodulation in diabetic wound healing",

abstract = "Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3β activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance. The occurrence of diabetic ulcers is linked to peripheral arterial disease, neuropathy, and wound contamination. Lasers or light emitting diodes (LEDs) provide photon energy with therapeutic benefits (Photobiomodulation-PBM), and has been broadly commended to quicken diabetic wound healing. PBM is efficient in the visible red and near-infrared electromagnetic spectrum, and fluencies ranging from 2 to 6 J/cm2. However, cellular and molecular mechanisms induced by PBM are not fully understood. In this review we discuss PBM and the PI3K/AKT pathway with specific focus on the mTOR and GSK3β downstream activity in diabetic wound healing.",

keywords = "AKT, Bcl2, Diabetes mellitus, Diabetic ulcers, GSK3, Growth factors, PI3K, Photobiomodulation, TOR, Wound healing",

author = "Jere, {Sandy W.} and Houreld, {Nicolette N.} and Heidi Abrahamse",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = dec,

doi = "10.1016/j.cytogfr.2019.03.001",

language = "English",

volume = "50",

pages = "52--59",

journal = "Cytokine and Growth Factor Reviews",

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TY - JOUR

T1 - Role of the PI3K/AKT (mTOR and GSK3β) signalling pathway and photobiomodulation in diabetic wound healing

AU - Jere, Sandy W.

AU - Houreld, Nicolette N.

AU - Abrahamse, Heidi

PY - 2019/12

Y1 - 2019/12

N2 - Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3β activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance. The occurrence of diabetic ulcers is linked to peripheral arterial disease, neuropathy, and wound contamination. Lasers or light emitting diodes (LEDs) provide photon energy with therapeutic benefits (Photobiomodulation-PBM), and has been broadly commended to quicken diabetic wound healing. PBM is efficient in the visible red and near-infrared electromagnetic spectrum, and fluencies ranging from 2 to 6 J/cm2. However, cellular and molecular mechanisms induced by PBM are not fully understood. In this review we discuss PBM and the PI3K/AKT pathway with specific focus on the mTOR and GSK3β downstream activity in diabetic wound healing.

AB - Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3β activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance. The occurrence of diabetic ulcers is linked to peripheral arterial disease, neuropathy, and wound contamination. Lasers or light emitting diodes (LEDs) provide photon energy with therapeutic benefits (Photobiomodulation-PBM), and has been broadly commended to quicken diabetic wound healing. PBM is efficient in the visible red and near-infrared electromagnetic spectrum, and fluencies ranging from 2 to 6 J/cm2. However, cellular and molecular mechanisms induced by PBM are not fully understood. In this review we discuss PBM and the PI3K/AKT pathway with specific focus on the mTOR and GSK3β downstream activity in diabetic wound healing.

KW - AKT

KW - Bcl2

KW - Diabetes mellitus

KW - Diabetic ulcers

KW - GSK3

KW - Growth factors

KW - PI3K

KW - Photobiomodulation

KW - TOR

KW - Wound healing

UR - http://www.scopus.com/inward/record.url?scp=85062906065&partnerID=8YFLogxK

U2 - 10.1016/j.cytogfr.2019.03.001

DO - 10.1016/j.cytogfr.2019.03.001

M3 - Short survey

C2 - 30890300

AN - SCOPUS:85062906065

SN - 1359-6101

VL - 50

SP - 52

EP - 59

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

ER -

Role of the PI3K/AKT (mTOR and GSK3β) signalling pathway and photobiomodulation in diabetic wound healing

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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