TY - JOUR
T1 - Role of Non-coding RNAs in the Response of Glioblastoma to Temozolomide
AU - Goleij, Pouya
AU - Pourali, Ghazaleh
AU - Raisi, Arash
AU - Ravaei, Fatemeh
AU - Golestan, Shahin
AU - Abed, Atena
AU - Razavi, Zahra Sadat
AU - Zarepour, Fatemeh
AU - Taghavi, Seyed Pouya
AU - Ahmadi Asouri, Sahar
AU - Rafiei, Moein
AU - Mousavi, Seyed Mojtaba
AU - Hamblin, Michael R.
AU - Talei, Sahand
AU - Sheida, Amirhossein
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2024
Y1 - 2024
N2 - Chemotherapy and radiotherapy are widely used in clinical practice across the globe as cancer treatments. Intrinsic or acquired chemoresistance poses a significant problem for medical practitioners and researchers, causing tumor recurrence and metastasis. The most dangerous kind of malignant brain tumor is called glioblastoma multiforme (GBM) that often recurs following surgery. The most often used medication for treating GBM is temozolomide chemotherapy; however, most patients eventually become resistant. Researchers are studying preclinical models that accurately reflect human disease and can be used to speed up drug development to overcome chemoresistance in GBM. Non-coding RNAs (ncRNAs) have been shown to be substantial in regulating tumor development and facilitating treatment resistance in several cancers, such as GBM. In this work, we mentioned the mechanisms of how different ncRNAs (microRNAs, long non-coding RNAs, circular RNAs) can regulate temozolomide chemosensitivity in GBM. We also address the role of these ncRNAs encapsulated inside secreted exosomes.
AB - Chemotherapy and radiotherapy are widely used in clinical practice across the globe as cancer treatments. Intrinsic or acquired chemoresistance poses a significant problem for medical practitioners and researchers, causing tumor recurrence and metastasis. The most dangerous kind of malignant brain tumor is called glioblastoma multiforme (GBM) that often recurs following surgery. The most often used medication for treating GBM is temozolomide chemotherapy; however, most patients eventually become resistant. Researchers are studying preclinical models that accurately reflect human disease and can be used to speed up drug development to overcome chemoresistance in GBM. Non-coding RNAs (ncRNAs) have been shown to be substantial in regulating tumor development and facilitating treatment resistance in several cancers, such as GBM. In this work, we mentioned the mechanisms of how different ncRNAs (microRNAs, long non-coding RNAs, circular RNAs) can regulate temozolomide chemosensitivity in GBM. We also address the role of these ncRNAs encapsulated inside secreted exosomes.
KW - Chemosensitivity
KW - Circular RNAs
KW - Exosomal Non-coding RNAs
KW - Glioblastoma Multiforme
KW - Long Non-coding RNAs
KW - MicroRNAs
KW - Temozolomide
UR - http://www.scopus.com/inward/record.url?scp=85198946810&partnerID=8YFLogxK
U2 - 10.1007/s12035-024-04316-z
DO - 10.1007/s12035-024-04316-z
M3 - Review article
AN - SCOPUS:85198946810
SN - 0893-7648
JO - Molecular Neurobiology
JF - Molecular Neurobiology
ER -