Role of Non-coding RNAs in the Response of Glioblastoma to Temozolomide

Pouya Goleij, Ghazaleh Pourali, Arash Raisi, Fatemeh Ravaei, Shahin Golestan, Atena Abed, Zahra Sadat Razavi, Fatemeh Zarepour, Seyed Pouya Taghavi, Sahar Ahmadi Asouri, Moein Rafiei, Seyed Mojtaba Mousavi, Michael R. Hamblin, Sahand Talei, Amirhossein Sheida, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

Abstract

Chemotherapy and radiotherapy are widely used in clinical practice across the globe as cancer treatments. Intrinsic or acquired chemoresistance poses a significant problem for medical practitioners and researchers, causing tumor recurrence and metastasis. The most dangerous kind of malignant brain tumor is called glioblastoma multiforme (GBM) that often recurs following surgery. The most often used medication for treating GBM is temozolomide chemotherapy; however, most patients eventually become resistant. Researchers are studying preclinical models that accurately reflect human disease and can be used to speed up drug development to overcome chemoresistance in GBM. Non-coding RNAs (ncRNAs) have been shown to be substantial in regulating tumor development and facilitating treatment resistance in several cancers, such as GBM. In this work, we mentioned the mechanisms of how different ncRNAs (microRNAs, long non-coding RNAs, circular RNAs) can regulate temozolomide chemosensitivity in GBM. We also address the role of these ncRNAs encapsulated inside secreted exosomes.

Original languageEnglish
JournalMolecular Neurobiology
DOIs
Publication statusAccepted/In press - 2024

Keywords

  • Chemosensitivity
  • Circular RNAs
  • Exosomal Non-coding RNAs
  • Glioblastoma Multiforme
  • Long Non-coding RNAs
  • MicroRNAs
  • Temozolomide

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Neurology
  • Cellular and Molecular Neuroscience

Fingerprint

Dive into the research topics of 'Role of Non-coding RNAs in the Response of Glioblastoma to Temozolomide'. Together they form a unique fingerprint.

Cite this