TY - JOUR
T1 - Role of non-coding RNAs in neuroblastoma
AU - Anoushirvani, Ali Arash
AU - Jafarian Yazdi, Arezoo
AU - Amirabadi, Sanaz
AU - Asouri, Sahar Ahmadi
AU - Shafabakhsh, Rana
AU - Sheida, Amirhossein
AU - Hosseini Khabr, Maryam Sadat
AU - Jafari, Ameneh
AU - Tamehri Zadeh, Seyed Saeed
AU - Hamblin, Michael R.
AU - Kalantari, Leila
AU - Talaei Zavareh, Sayyed Alireza
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2023/9
Y1 - 2023/9
N2 - Neuroblastoma is known as the most prevalent extracranial malignancy in childhood with a neural crest origin. It has been widely accepted that non-coding RNAs (ncRNAs) play important roles in many types of cancer, including glioma and gastrointestinal cancers. They may regulate the cancer gene network. According to recent sequencing and profiling studies, ncRNAs genes are deregulated in human cancers via deletion, amplification, abnormal epigenetic, or transcriptional regulation. Disturbances in the expression of ncRNAs may act either as oncogenes or as anti-tumor suppressor genes, and can lead to the induction of cancer hallmarks. ncRNAs can be secreted from tumor cells inside exosomes, where they can be transferred to other cells to affect their function. However, these topics still need more study to clarify their exact roles, so the present review addresses different roles and functions of ncRNAs in neuroblastoma.
AB - Neuroblastoma is known as the most prevalent extracranial malignancy in childhood with a neural crest origin. It has been widely accepted that non-coding RNAs (ncRNAs) play important roles in many types of cancer, including glioma and gastrointestinal cancers. They may regulate the cancer gene network. According to recent sequencing and profiling studies, ncRNAs genes are deregulated in human cancers via deletion, amplification, abnormal epigenetic, or transcriptional regulation. Disturbances in the expression of ncRNAs may act either as oncogenes or as anti-tumor suppressor genes, and can lead to the induction of cancer hallmarks. ncRNAs can be secreted from tumor cells inside exosomes, where they can be transferred to other cells to affect their function. However, these topics still need more study to clarify their exact roles, so the present review addresses different roles and functions of ncRNAs in neuroblastoma.
UR - http://www.scopus.com/inward/record.url?scp=85160076066&partnerID=8YFLogxK
U2 - 10.1038/s41417-023-00623-0
DO - 10.1038/s41417-023-00623-0
M3 - Review article
C2 - 37217790
AN - SCOPUS:85160076066
SN - 0929-1903
VL - 30
SP - 1190
EP - 1208
JO - Cancer Gene Therapy
JF - Cancer Gene Therapy
IS - 9
ER -