Role of non-coding RNAs in neuroblastoma

Ali Arash Anoushirvani, Arezoo Jafarian Yazdi, Sanaz Amirabadi, Sahar Ahmadi Asouri, Rana Shafabakhsh, Amirhossein Sheida, Maryam Sadat Hosseini Khabr, Ameneh Jafari, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Leila Kalantari, Sayyed Alireza Talaei Zavareh, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Neuroblastoma is known as the most prevalent extracranial malignancy in childhood with a neural crest origin. It has been widely accepted that non-coding RNAs (ncRNAs) play important roles in many types of cancer, including glioma and gastrointestinal cancers. They may regulate the cancer gene network. According to recent sequencing and profiling studies, ncRNAs genes are deregulated in human cancers via deletion, amplification, abnormal epigenetic, or transcriptional regulation. Disturbances in the expression of ncRNAs may act either as oncogenes or as anti-tumor suppressor genes, and can lead to the induction of cancer hallmarks. ncRNAs can be secreted from tumor cells inside exosomes, where they can be transferred to other cells to affect their function. However, these topics still need more study to clarify their exact roles, so the present review addresses different roles and functions of ncRNAs in neuroblastoma.

Original languageEnglish
Pages (from-to)1190-1208
Number of pages19
JournalCancer Gene Therapy
Volume30
Issue number9
DOIs
Publication statusPublished - Sept 2023

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cancer Research

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