TY - JOUR
T1 - Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression
AU - Ahangar Davoodi, Nasrin
AU - Najafi, Sajad
AU - Naderi Ghale-Noie, Zari
AU - Piranviseh, Ashkan
AU - Mollazadeh, Samaneh
AU - Ahmadi Asouri, Sahar
AU - Asemi, Zatollah
AU - Morshedi, Mohammadamin
AU - Tamehri Zadeh, Seyed Saeed
AU - Hamblin, Michael R.
AU - Sheida, Amirhossein
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
Copyright © 2022 Ahangar Davoodi, Najafi, Naderi Ghale-Noie, Piranviseh, Mollazadeh, Ahmadi Asouri, Asemi, Morshedi, Tamehri Zadeh, Hamblin, Sheida and Mirzaei.
PY - 2022/12/23
Y1 - 2022/12/23
N2 - Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that has the potential to affect vision, and can even be fatal in some children. While the tumor can be controlled efficiently at early stages, metastatic tumors lead to high mortality. Non-coding RNAs (ncRNAs) are implicated in a number of physiological cellular process, including differentiation, proliferation, migration, and invasion, The deregulation of ncRNAs is correlated with several diseases, particularly cancer. ncRNAs are categorized into two main groups based on their length, i.e. short and long ncRNAs. Moreover, ncRNA deregulation has been demonstrated to play a role in the pathogenesis and development of RB. Several ncRNAs, such as miR-491-3p, miR-613,and SUSD2 have been found to act as tumor suppressor genes in RB, but other ncRNAs, such as circ-E2F3, NEAT1, and TUG1 act as tumor promoter genes. Understanding the regulatory mechanisms of ncRNAs can provide new opportunities for RB therapy. In the present review, we discuss the functional roles of the most important ncRNAs in RB, their interaction with the genes responsible for RB initiation and progression, and possible future clinical applications as diagnostic and prognostic tools or as therapeutic targets.
AB - Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that has the potential to affect vision, and can even be fatal in some children. While the tumor can be controlled efficiently at early stages, metastatic tumors lead to high mortality. Non-coding RNAs (ncRNAs) are implicated in a number of physiological cellular process, including differentiation, proliferation, migration, and invasion, The deregulation of ncRNAs is correlated with several diseases, particularly cancer. ncRNAs are categorized into two main groups based on their length, i.e. short and long ncRNAs. Moreover, ncRNA deregulation has been demonstrated to play a role in the pathogenesis and development of RB. Several ncRNAs, such as miR-491-3p, miR-613,and SUSD2 have been found to act as tumor suppressor genes in RB, but other ncRNAs, such as circ-E2F3, NEAT1, and TUG1 act as tumor promoter genes. Understanding the regulatory mechanisms of ncRNAs can provide new opportunities for RB therapy. In the present review, we discuss the functional roles of the most important ncRNAs in RB, their interaction with the genes responsible for RB initiation and progression, and possible future clinical applications as diagnostic and prognostic tools or as therapeutic targets.
KW - Retinoblastma
KW - circular RNA
KW - exosome
KW - microRNA
KW - non-coding RNAs
UR - http://www.scopus.com/inward/record.url?scp=85145721323&partnerID=8YFLogxK
U2 - 10.3389/fcell.2022.1065837
DO - 10.3389/fcell.2022.1065837
M3 - Review article
AN - SCOPUS:85145721323
SN - 2296-634X
VL - 10
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
M1 - 1065837
ER -