Resveratrol in Cancer Treatment with a Focus on Breast Cancer

  • Hamed Kowsari
  • , Amirhossein Davoodvandi
  • , Fatemeh Dashti
  • , Seyed Mohamad Ali Mirazimi
  • , Zahra Razaghi Bahabadi
  • , Michael Aschner
  • , Amirhossein Sahebkar
  • , Hamid Reza Gilasi
  • , Michael R. Hamblin
  • , Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)

Abstract

Acute liver injury (ALI) is a critical and fatal disorder associated with excessive Alt-hough considerable advances have been made in the early diagnosis and treatment of breast cancer, it is still one of the major causes of global cancer-related death in women over the last several decades. Phytochemicals have been shown to be promising agents in the prevention and treatment of breast cancer. Resveratrol is an important plant-derived polyphenolic compound with a variety of potent biological activities. It has been suggested that resveratrol can be used to prevent and treat various types of cancer, including breast cancer. Resveratrol can affect nu-merous signaling pathways in vitro, leading to the induction of cell cycle arrest and apoptosis, suppression of proliferation, reduction of inflammatory responses, and the inhibition of angio-genesis and metastasis. Nevertheless, studies of resveratrol in animal models of breast cancer have so far been disappointing.

Original languageEnglish
Pages (from-to)346-361
Number of pages16
JournalCurrent Molecular Pharmacology
Volume16
Issue number3
DOIs
Publication statusPublished - 2023

Keywords

  • Breast cancer
  • cancer therapy
  • chemotherapy
  • phytochemicals
  • resveratrol
  • signaling pathways

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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