TY - JOUR
T1 - Resveratrol in Cancer Treatment with a Focus on Breast Cancer
AU - Kowsari, Hamed
AU - Davoodvandi, Amirhossein
AU - Dashti, Fatemeh
AU - Mirazimi, Seyed Mohamad Ali
AU - Bahabadi, Zahra Razaghi
AU - Aschner, Michael
AU - Sahebkar, Amirhossein
AU - Gilasi, Hamid Reza
AU - Hamblin, Michael R.
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© 2023 Bentham Science Publishers.
PY - 2023
Y1 - 2023
N2 - Acute liver injury (ALI) is a critical and fatal disorder associated with excessive Alt-hough considerable advances have been made in the early diagnosis and treatment of breast cancer, it is still one of the major causes of global cancer-related death in women over the last several decades. Phytochemicals have been shown to be promising agents in the prevention and treatment of breast cancer. Resveratrol is an important plant-derived polyphenolic compound with a variety of potent biological activities. It has been suggested that resveratrol can be used to prevent and treat various types of cancer, including breast cancer. Resveratrol can affect nu-merous signaling pathways in vitro, leading to the induction of cell cycle arrest and apoptosis, suppression of proliferation, reduction of inflammatory responses, and the inhibition of angio-genesis and metastasis. Nevertheless, studies of resveratrol in animal models of breast cancer have so far been disappointing.
AB - Acute liver injury (ALI) is a critical and fatal disorder associated with excessive Alt-hough considerable advances have been made in the early diagnosis and treatment of breast cancer, it is still one of the major causes of global cancer-related death in women over the last several decades. Phytochemicals have been shown to be promising agents in the prevention and treatment of breast cancer. Resveratrol is an important plant-derived polyphenolic compound with a variety of potent biological activities. It has been suggested that resveratrol can be used to prevent and treat various types of cancer, including breast cancer. Resveratrol can affect nu-merous signaling pathways in vitro, leading to the induction of cell cycle arrest and apoptosis, suppression of proliferation, reduction of inflammatory responses, and the inhibition of angio-genesis and metastasis. Nevertheless, studies of resveratrol in animal models of breast cancer have so far been disappointing.
KW - Breast cancer
KW - cancer therapy
KW - chemotherapy
KW - phytochemicals
KW - resveratrol
KW - signaling pathways
UR - http://www.scopus.com/inward/record.url?scp=85149259423&partnerID=8YFLogxK
U2 - 10.2174/1874467215666220616145216
DO - 10.2174/1874467215666220616145216
M3 - Review article
C2 - 35713130
AN - SCOPUS:85149259423
SN - 1874-4672
VL - 16
SP - 346
EP - 361
JO - Current Molecular Pharmacology
JF - Current Molecular Pharmacology
IS - 3
ER -