Resveratrol in Cancer Treatment with a Focus on Breast Cancer

Hamed Kowsari, Amirhossein Davoodvandi, Fatemeh Dashti, Seyed Mohamad Ali Mirazimi, Zahra Razaghi Bahabadi, Michael Aschner, Amirhossein Sahebkar, Hamid Reza Gilasi, Michael R. Hamblin, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Acute liver injury (ALI) is a critical and fatal disorder associated with excessive Alt-hough considerable advances have been made in the early diagnosis and treatment of breast cancer, it is still one of the major causes of global cancer-related death in women over the last several decades. Phytochemicals have been shown to be promising agents in the prevention and treatment of breast cancer. Resveratrol is an important plant-derived polyphenolic compound with a variety of potent biological activities. It has been suggested that resveratrol can be used to prevent and treat various types of cancer, including breast cancer. Resveratrol can affect nu-merous signaling pathways in vitro, leading to the induction of cell cycle arrest and apoptosis, suppression of proliferation, reduction of inflammatory responses, and the inhibition of angio-genesis and metastasis. Nevertheless, studies of resveratrol in animal models of breast cancer have so far been disappointing.

Original languageEnglish
Pages (from-to)346-361
Number of pages16
JournalCurrent Molecular Pharmacology
Volume16
Issue number3
DOIs
Publication statusPublished - 2023

Keywords

  • Breast cancer
  • cancer therapy
  • chemotherapy
  • phytochemicals
  • resveratrol
  • signaling pathways

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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