TY - JOUR
T1 - Regulatory role of microRNAs in virus-mediated inflammation
AU - Bannazadeh Baghi, Hossein
AU - Bayat, Mobina
AU - Mehrasa, Parisa
AU - Alavi, Seyed Mohammad Amin
AU - Lotfalizadeh, Mohammad Hassan
AU - Memar, Mohammad Yousef
AU - Taghavi, Seyed Pouya
AU - Zarepour, Fatemeh
AU - Hamblin, Michael R.
AU - Sadri Nahand, Javid
AU - Hashemian, Seyed Mohammad Reza
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Viral infections in humans often cause excessive inflammation. In some viral infections, inflammation can be serious and even fatal, while in other infections it can promote viral clearance. Viruses can escape from the host immune system via regulating inflammatory pathways, thus worsening the illness. MicroRNAs (miRNAs) are tiny non-coding RNA molecules expressed within diverse tissues as well as cells and are engaged in different normal pathological and physiological pathways. Emerging proof suggests that miRNAs can impact innate and adaptive immunity, inflammatory responses, cell invasion, and the progression of viral infections. We discuss some intriguing new findings in the current work, focusing on the impacts of different miRNAs on host inflammatory responses and virus-mediated inflammation. A better understanding of dysregulated miRNAs in viral infections could improve the identification, prevention, and treatment of several serious diseases.
AB - Viral infections in humans often cause excessive inflammation. In some viral infections, inflammation can be serious and even fatal, while in other infections it can promote viral clearance. Viruses can escape from the host immune system via regulating inflammatory pathways, thus worsening the illness. MicroRNAs (miRNAs) are tiny non-coding RNA molecules expressed within diverse tissues as well as cells and are engaged in different normal pathological and physiological pathways. Emerging proof suggests that miRNAs can impact innate and adaptive immunity, inflammatory responses, cell invasion, and the progression of viral infections. We discuss some intriguing new findings in the current work, focusing on the impacts of different miRNAs on host inflammatory responses and virus-mediated inflammation. A better understanding of dysregulated miRNAs in viral infections could improve the identification, prevention, and treatment of several serious diseases.
KW - Host microRNAs
KW - Immune responses
KW - Respiratory infections
KW - Viral inflammation
KW - Viral miRNAs
UR - http://www.scopus.com/inward/record.url?scp=85208640358&partnerID=8YFLogxK
U2 - 10.1186/s12950-024-00417-7
DO - 10.1186/s12950-024-00417-7
M3 - Review article
AN - SCOPUS:85208640358
SN - 1476-9255
VL - 21
JO - Journal of Inflammation
JF - Journal of Inflammation
IS - 1
M1 - 43
ER -