Regioselective Synthesis of 1,5-Disubstituted 1,2,3-Triazoles by Reusable AlCl3 Immobilized on γ-Al2O3

Hemmaragala M. Nanjundaswamy, Heidi Abrahamse

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

(Chemical Equation Presented) There is rapidly growing interest in the synthesis and use of substituted 1,2,3-triazoles. We report an easy and interesting procedure that demonstrates the effectiveness of surface-modified γ-Al2O3, which is reusable, efficient, catalytic, safe, and environmentally acceptable for the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via [3 + 2] cycloaddition of phenyl and benzyl azides with a series of aryl nitroolefins in good yields. No adverse effect on substituents such as nitro, cyano, hydroxy, ether linkage, and halogens was observed. The catalyst could easily be recycled and was reused for nine runs without losing its activity.

Original languageEnglish
Pages (from-to)967-974
Number of pages8
JournalSynthetic Communications
Volume45
Issue number8
DOIs
Publication statusPublished - 2015

Keywords

  • 1,5-disubstituted-1,2,3-3-triazoles
  • Azide
  • [3 + 2] cycloaddition
  • immobilized AlCl on γ-AlO
  • nitroolefins

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Regioselective Synthesis of 1,5-Disubstituted 1,2,3-Triazoles by Reusable AlCl3 Immobilized on γ-Al2O3'. Together they form a unique fingerprint.

Cite this