TY - JOUR
T1 - Recent advances on silver nanoparticle and biopolymer-based biomaterials for wound healing applications
AU - Kumar, Sathish Sundar Dhilip
AU - Rajendran, Naresh Kumar
AU - Houreld, Nicolette Nadene
AU - Abrahamse, Heidi
N1 - Publisher Copyright:
© 2018
PY - 2018/8
Y1 - 2018/8
N2 - Silver nanoparticles (AgNPs) are classified as metal-based nanoparticles and have gained considerable attention amongst researchers in wound healing applications, owing to their physicochemical and biological properties. Biopolymers are abundantly available from natural sources and are used in numerous applications in pharmaceutical sciences and medicine. Silver nanoparticles and biopolymer-based biomaterials (AgNP-BMs) are non-cytotoxic and safe for patients in wound care management. The unique intrinsic features of AgNP-BMs promote wound healing and effectively control the growth of microorganisms at the wound site, and this strategy plays an important role in the treatment of both acute and chronic wounds. In this review article, we focus on the advanced therapeutic approaches of AgNP-BMs and their potential role in wound healing applications, which includes multifunctional properties, antimicrobial activities and various forms of AgNP-BMs. Moreover, the review briefly recaps on recent progress made in biopolymers, silver, AgNPs and their potential role in clinical research and a commercial platform for the treatment of wounds. Silver nanoparticle and biopolymer-based biomaterial offers a high-degree of biocompatibility and biodegradability in physiological conditions and can be considered as an effective material for wound dressings in the treatment of different wounds.
AB - Silver nanoparticles (AgNPs) are classified as metal-based nanoparticles and have gained considerable attention amongst researchers in wound healing applications, owing to their physicochemical and biological properties. Biopolymers are abundantly available from natural sources and are used in numerous applications in pharmaceutical sciences and medicine. Silver nanoparticles and biopolymer-based biomaterials (AgNP-BMs) are non-cytotoxic and safe for patients in wound care management. The unique intrinsic features of AgNP-BMs promote wound healing and effectively control the growth of microorganisms at the wound site, and this strategy plays an important role in the treatment of both acute and chronic wounds. In this review article, we focus on the advanced therapeutic approaches of AgNP-BMs and their potential role in wound healing applications, which includes multifunctional properties, antimicrobial activities and various forms of AgNP-BMs. Moreover, the review briefly recaps on recent progress made in biopolymers, silver, AgNPs and their potential role in clinical research and a commercial platform for the treatment of wounds. Silver nanoparticle and biopolymer-based biomaterial offers a high-degree of biocompatibility and biodegradability in physiological conditions and can be considered as an effective material for wound dressings in the treatment of different wounds.
KW - Silver nanoparticles
KW - antimicrobial activity
KW - biomaterial
KW - biopolymer
KW - polysaccharides
KW - wound healing
UR - http://www.scopus.com/inward/record.url?scp=85045543252&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2018.04.003
DO - 10.1016/j.ijbiomac.2018.04.003
M3 - Review article
C2 - 29627463
AN - SCOPUS:85045543252
SN - 0141-8130
VL - 115
SP - 165
EP - 175
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -