TY - JOUR
T1 - PZQ therapy
T2 - How close are we in the development of effective alternative anti-schistosomal drugs?
AU - Aruleba, Raphael Taiwo
AU - Adekiya, Tayo Alex
AU - Oyinloye, Babatunji Emmanuel
AU - Masamba, Priscilla
AU - Mbatha, Londiwe Simphiwe
AU - Pretorius, Ashley
AU - Kappo, Abidemi Paul
N1 - Publisher Copyright:
© 2019 Bentham Science Publishers.
PY - 2019
Y1 - 2019
N2 - Today schistosomiasis, caused mainly by the three major schistosome species (S. mansoni, S. haematobium and S. japonicum), has for many decades and still continues to be on a rapid and swift rise globally, claiming thousands of lives every year and leaving 800 million people at the risk of infection. Due to the high prevalence of this disease and the steady increase in the infection rates, praziquantel (PZQ) remains the only effective drug against this acute disease although it has no effect on the juvenile schistosome parasite. However, no significant approaches have been made in recent years in the discovery of new or alternative drugs and unfortunately, resistance to this drug has been reported in some parts of the world. Therefore, it is imperative to develop a new drug for this debilitating disease. In this review, a brief history of past, present, and new promising anti-schistosomal drugs is presented.
AB - Today schistosomiasis, caused mainly by the three major schistosome species (S. mansoni, S. haematobium and S. japonicum), has for many decades and still continues to be on a rapid and swift rise globally, claiming thousands of lives every year and leaving 800 million people at the risk of infection. Due to the high prevalence of this disease and the steady increase in the infection rates, praziquantel (PZQ) remains the only effective drug against this acute disease although it has no effect on the juvenile schistosome parasite. However, no significant approaches have been made in recent years in the discovery of new or alternative drugs and unfortunately, resistance to this drug has been reported in some parts of the world. Therefore, it is imperative to develop a new drug for this debilitating disease. In this review, a brief history of past, present, and new promising anti-schistosomal drugs is presented.
KW - Drugs
KW - Praziquantel
KW - Schistosoma haematobium
KW - Schistosoma mansoni
KW - Schistosome
KW - Schistosomiasis
UR - http://www.scopus.com/inward/record.url?scp=85077255273&partnerID=8YFLogxK
U2 - 10.2174/1871526519666181231153139
DO - 10.2174/1871526519666181231153139
M3 - Review article
C2 - 30599112
AN - SCOPUS:85077255273
SN - 1871-5265
VL - 19
SP - 337
EP - 349
JO - Infectious Disorders - Drug Targets
JF - Infectious Disorders - Drug Targets
IS - 4
ER -