Pyroptosis and the tumor immune microenvironment: A new battlefield in ovarian cancer treatment

Aihong Wang, Yin Wang, Chenxiang Du, Huilun Yang, Zhengping Wang, Canhui Jin, Michael R. Hamblin

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Ovarian cancer is a less common tumor in women compared to cervical or breast cancer, however it is more malignant and has worse outcomes. Ovarian cancer patients still have a five-year survival rate < 50% despite advances in therapy. Due to recent developments in immune checkpoint inhibitors (ICIs), cancer immunotherapy has attracted increased interest. Pyroptosis is a highly inflammatory form of cell death, which is essential for bridging innate and adaptive immunity, and is involved in immune regulation within the tumor microenvironment (TME). Recent research has shown that pyroptosis can promote immunotherapy of ovarian cancer, including treatment with chimeric antigen receptor T-cells (CAR-T) or ICIs. Moreover, inflammasomes, various signaling pathways and lncRNAs can all affect pyroptosis in ovarian cancer. Here we discuss how pyroptosis affects the development and progression of ovarian cancer as well as the TME. We also provide a summary of small molecule drugs that could target pyroptotic cell death processes and may be useful in ovarian cancer therapy.

Original languageEnglish
Article number189058
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1879
Issue number2
DOIs
Publication statusPublished - Mar 2024

Keywords

  • Gasdermin D
  • Immune checkpoint inhibitors
  • Inflammasomes: Tumor microenvironment
  • Inflammatory cell death
  • Programmed cell death

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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