Preparation of β-Cyclodextrin Conjugated, Gelatin Stabilized SBA 15-CuInS2/ZnS Quantum Dot Nanocomposites for Camptothecin Release

Jose Varghese Rajendran, Sundararajan Parani, Vasudevan Pillay R. Remya, Thabang C. Lebepe, Rodney Maluleke, Olanrewaju A. Aladesuyi, Sabu Thomas, Oluwatobi Samuel Oluwafemi

Research output: Contribution to journalArticlepeer-review

Abstract

Camptothecin (CPT) is a potential anticancer drug. However, it faces challenges due to its poor water solubility and the need for an efficient drug release system. Herein, we developed a novel system composed of gelatin stabilized, mesoporous silica SBA15 encapsulated CuInS2/ZnS (CIS/ZnS) quantum dots (QDs) conjugated with β-cyclodextrin (β-CDs) for its potential use in the release of CPT. In this multifunctional system, β-CDs served as the drug carrier, SBA15 encapsulated QDs is capable of imaging and the gelatin was used to enhance the carrier-drug interaction. Fourier transform infrared (FTIR) analysis confirmed the successful conjugation of β-CDs to the Gel-SBA15 CIS/ZnS QDs, while optical analyses revealed excellent emission properties and high photostability. The β-CD-conjugated Gel-SBA15-CIS/ZnS QD nanocomposite was used to obtain the soluble derivate of CPT which further demonstrated a drug release profile following the triphasic model. Overall, the improved photostability and acceptable drug release profile of the β-CD conjugated Gel-SBA15-CIS/ZnS QD nanocomposite hold great promise for both imaging and therapeutic applications. Graphical Abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalJournal of Inorganic and Organometallic Polymers and Materials
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 2024

Keywords

  • Drug delivery
  • Mesoporous silica
  • Photostability
  • Quantum dots

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Preparation of β-Cyclodextrin Conjugated, Gelatin Stabilized SBA 15-CuInS2/ZnS Quantum Dot Nanocomposites for Camptothecin Release'. Together they form a unique fingerprint.

Cite this