Pre-exposure prophylaxis and antiretroviral treatment interventions with drug resistance

Komi Afassinou; Faraimunashe Chirove; Keshlan S. Govinder

doi:10.1016/j.mbs.2017.01.005

Pre-exposure prophylaxis and antiretroviral treatment interventions with drug resistance

Komi Afassinou, Faraimunashe Chirove, Keshlan S. Govinder

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

Abstract

We introduce a model for HIV/AIDS which can be utilized to assess the impact of combining pre-exposure prophylaxis (PrEP) and antiretroviral drugs (ARVs) use interventions (incorporating drug resistance). Mathematical and numerical analyses are carried out to investigate the effects of the combined controls in the presence of PrEP drug resistance. Our results predict a significant decrease in the number of new HIV infections when PrEP and ARVs are concurrently implemented at high levels. The results also reveal that PrEP drug resistance has the potential to slow down or reverse the effects of PrEP, especially at low efficacy levels.

Original language	English
Pages (from-to)	92-101
Number of pages	10
Journal	Mathematical Biosciences
Volume	285
DOIs	https://doi.org/10.1016/j.mbs.2017.01.005
Publication status	Published - 1 Mar 2017
Externally published	Yes

Keywords

Prep awareness
Prep drug resistance
Prep efficacy

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences
Applied Mathematics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mbs.2017.01.005

Cite this

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title = "Pre-exposure prophylaxis and antiretroviral treatment interventions with drug resistance",

abstract = "We introduce a model for HIV/AIDS which can be utilized to assess the impact of combining pre-exposure prophylaxis (PrEP) and antiretroviral drugs (ARVs) use interventions (incorporating drug resistance). Mathematical and numerical analyses are carried out to investigate the effects of the combined controls in the presence of PrEP drug resistance. Our results predict a significant decrease in the number of new HIV infections when PrEP and ARVs are concurrently implemented at high levels. The results also reveal that PrEP drug resistance has the potential to slow down or reverse the effects of PrEP, especially at low efficacy levels.",

keywords = "Prep awareness, Prep drug resistance, Prep efficacy",

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doi = "10.1016/j.mbs.2017.01.005",

language = "English",

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TY - JOUR

T1 - Pre-exposure prophylaxis and antiretroviral treatment interventions with drug resistance

AU - Afassinou, Komi

AU - Chirove, Faraimunashe

AU - Govinder, Keshlan S.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - We introduce a model for HIV/AIDS which can be utilized to assess the impact of combining pre-exposure prophylaxis (PrEP) and antiretroviral drugs (ARVs) use interventions (incorporating drug resistance). Mathematical and numerical analyses are carried out to investigate the effects of the combined controls in the presence of PrEP drug resistance. Our results predict a significant decrease in the number of new HIV infections when PrEP and ARVs are concurrently implemented at high levels. The results also reveal that PrEP drug resistance has the potential to slow down or reverse the effects of PrEP, especially at low efficacy levels.

AB - We introduce a model for HIV/AIDS which can be utilized to assess the impact of combining pre-exposure prophylaxis (PrEP) and antiretroviral drugs (ARVs) use interventions (incorporating drug resistance). Mathematical and numerical analyses are carried out to investigate the effects of the combined controls in the presence of PrEP drug resistance. Our results predict a significant decrease in the number of new HIV infections when PrEP and ARVs are concurrently implemented at high levels. The results also reveal that PrEP drug resistance has the potential to slow down or reverse the effects of PrEP, especially at low efficacy levels.

KW - Prep awareness

KW - Prep drug resistance

KW - Prep efficacy

UR - http://www.scopus.com/inward/record.url?scp=85009468619&partnerID=8YFLogxK

U2 - 10.1016/j.mbs.2017.01.005

DO - 10.1016/j.mbs.2017.01.005

M3 - Review article

C2 - 28095307

AN - SCOPUS:85009468619

SN - 0025-5564

VL - 285

SP - 92

EP - 101

JO - Mathematical Biosciences

JF - Mathematical Biosciences

ER -

Pre-exposure prophylaxis and antiretroviral treatment interventions with drug resistance

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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