Potentiation of antimicrobial photodynamic inactivation mediated by a cationic fullerene by added iodide: In vitro and in vivo studies

Yunsong Zhang; Tianhong Dai; Min Wang; Daniela Vecchio; Long Y. Chiang; Michael R. Hamblin

doi:10.2217/nnm.14.131

Potentiation of antimicrobial photodynamic inactivation mediated by a cationic fullerene by added iodide: In vitro and in vivo studies

Yunsong Zhang, Tianhong Dai, Min Wang, Daniela Vecchio, Long Y. Chiang, Michael R. Hamblin

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

Abstract

Background: Antimicrobial photodynamic inactivation with fullerenes bearing cationic charges may overcome resistant microbes. Methods & results: We synthesized C₆₀-fullerene (LC16) bearing decaquaternary chain and deca-tertiary-amino groups that facilitates electron-transfer reactions via the photoexcited fullerene. Addition of the harmless salt, potassium iodide (10 mM) potentiated the ultraviolet A (UVA) or white light-mediated killing of Gram-negative bacteria Acinetobacter baumannii, Gram-positive methicillin-resistant Staphylococcus aureus and fungal yeast Candida albicans by 1-2+ logs. Mouse model infected with bioluminescent Acinetobacter baumannii gave increased loss of bioluminescence when iodide (10 mM) was combined with LC16 and UVA/white light. Conclusion: The mechanism may involve photoinduced electron reduction of ¹(C₆₀>)∗ or ³(C₆₀>)∗ by iodide producing I· or I₂ followed by subsequent intermolecular electron-transfer events of (C₆₀>)^-· to produce reactive radicals.

Original language	English
Pages (from-to)	603-614
Number of pages	12
Journal	Nanomedicine
Volume	10
Issue number	4
DOIs	https://doi.org/10.2217/nnm.14.131
Publication status	Published - 1 Mar 2015
Externally published	Yes

Keywords

antimicrobial photodynamic therapy
bioluminescent bacteria
decacationic fullerene
decatertiary-amine chain
in vivo infection model
iodide potentiation

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science
Development

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@article{f9990223ad124ec1bca1ad9b38e1a151,

title = "Potentiation of antimicrobial photodynamic inactivation mediated by a cationic fullerene by added iodide: In vitro and in vivo studies",

abstract = "Background: Antimicrobial photodynamic inactivation with fullerenes bearing cationic charges may overcome resistant microbes. Methods \& results: We synthesized C60-fullerene (LC16) bearing decaquaternary chain and deca-tertiary-amino groups that facilitates electron-transfer reactions via the photoexcited fullerene. Addition of the harmless salt, potassium iodide (10 mM) potentiated the ultraviolet A (UVA) or white light-mediated killing of Gram-negative bacteria Acinetobacter baumannii, Gram-positive methicillin-resistant Staphylococcus aureus and fungal yeast Candida albicans by 1-2+ logs. Mouse model infected with bioluminescent Acinetobacter baumannii gave increased loss of bioluminescence when iodide (10 mM) was combined with LC16 and UVA/white light. Conclusion: The mechanism may involve photoinduced electron reduction of 1(C60>)∗ or 3(C60>)∗ by iodide producing I· or I2 followed by subsequent intermolecular electron-transfer events of (C60>)-· to produce reactive radicals.",

keywords = "antimicrobial photodynamic therapy, bioluminescent bacteria, decacationic fullerene, decatertiary-amine chain, in vivo infection model, iodide potentiation",

author = "Yunsong Zhang and Tianhong Dai and Min Wang and Daniela Vecchio and Chiang, \{Long Y.\} and Hamblin, \{Michael R.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Future Medicine Ltd.",

year = "2015",

month = mar,

day = "1",

doi = "10.2217/nnm.14.131",

language = "English",

volume = "10",

pages = "603--614",

journal = "Nanomedicine",

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T1 - Potentiation of antimicrobial photodynamic inactivation mediated by a cationic fullerene by added iodide

T2 - In vitro and in vivo studies

AU - Zhang, Yunsong

AU - Dai, Tianhong

AU - Wang, Min

AU - Vecchio, Daniela

AU - Chiang, Long Y.

AU - Hamblin, Michael R.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background: Antimicrobial photodynamic inactivation with fullerenes bearing cationic charges may overcome resistant microbes. Methods & results: We synthesized C60-fullerene (LC16) bearing decaquaternary chain and deca-tertiary-amino groups that facilitates electron-transfer reactions via the photoexcited fullerene. Addition of the harmless salt, potassium iodide (10 mM) potentiated the ultraviolet A (UVA) or white light-mediated killing of Gram-negative bacteria Acinetobacter baumannii, Gram-positive methicillin-resistant Staphylococcus aureus and fungal yeast Candida albicans by 1-2+ logs. Mouse model infected with bioluminescent Acinetobacter baumannii gave increased loss of bioluminescence when iodide (10 mM) was combined with LC16 and UVA/white light. Conclusion: The mechanism may involve photoinduced electron reduction of 1(C60>)∗ or 3(C60>)∗ by iodide producing I· or I2 followed by subsequent intermolecular electron-transfer events of (C60>)-· to produce reactive radicals.

AB - Background: Antimicrobial photodynamic inactivation with fullerenes bearing cationic charges may overcome resistant microbes. Methods & results: We synthesized C60-fullerene (LC16) bearing decaquaternary chain and deca-tertiary-amino groups that facilitates electron-transfer reactions via the photoexcited fullerene. Addition of the harmless salt, potassium iodide (10 mM) potentiated the ultraviolet A (UVA) or white light-mediated killing of Gram-negative bacteria Acinetobacter baumannii, Gram-positive methicillin-resistant Staphylococcus aureus and fungal yeast Candida albicans by 1-2+ logs. Mouse model infected with bioluminescent Acinetobacter baumannii gave increased loss of bioluminescence when iodide (10 mM) was combined with LC16 and UVA/white light. Conclusion: The mechanism may involve photoinduced electron reduction of 1(C60>)∗ or 3(C60>)∗ by iodide producing I· or I2 followed by subsequent intermolecular electron-transfer events of (C60>)-· to produce reactive radicals.

KW - antimicrobial photodynamic therapy

KW - bioluminescent bacteria

KW - decacationic fullerene

KW - decatertiary-amine chain

KW - in vivo infection model

KW - iodide potentiation

UR - https://www.scopus.com/pages/publications/84924173483

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DO - 10.2217/nnm.14.131

M3 - Article

C2 - 25723093

AN - SCOPUS:84924173483

SN - 1743-5889

VL - 10

SP - 603

EP - 614

JO - Nanomedicine

JF - Nanomedicine

IS - 4

ER -

Potentiation of antimicrobial photodynamic inactivation mediated by a cationic fullerene by added iodide: In vitro and in vivo studies

Abstract

Keywords

ASJC Scopus subject areas

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