Polylysine for skin regeneration: A review of recent advances and future perspectives

Payam Zarrintaj, Sadegh Ghorbani, Mahmood Barani, Narendra Pal Singh Chauhan, Mohsen Khodadadi Yazdi, Mohammad Reza Saeb, Joshua D. Ramsey, Michael R. Hamblin, Masoud Mozafari, Ebrahim Mostafavi

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)


There have been several attempts to find promising biomaterials for skin regeneration, among which polylysine (a homopolypeptide) has shown benefits in the regeneration and treatment of skin disorders. This class of biomaterials has shown exceptional abilities due to their macromolecular structure. Polylysine-based biomaterials can be used as tissue engineering scaffolds for skin regeneration, and as drug carriers or even gene delivery vectors for the treatment of skin diseases. In addition, polylysine can play a preservative role in extending the lifetime of skin tissue by minimizing the appearance of photodamaged skin. Research on polylysine is growing today, opening new scenarios that expand the potential of these biomaterials from traditional treatments to a new era of tissue regeneration. This review aims to address the basic concepts, recent trends, and prospects of polylysine-based biomaterials for skin regeneration. Undoubtedly, this class of biomaterials needs further evaluations and explorations, and many critical questions have yet to be answered.

Original languageEnglish
Article numbere10261
JournalBioengineering and Translational Medicine
Issue number1
Publication statusPublished - Jan 2022

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Pharmaceutical Science


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