TY - JOUR
T1 - Polylysine for skin regeneration
T2 - A review of recent advances and future perspectives
AU - Zarrintaj, Payam
AU - Ghorbani, Sadegh
AU - Barani, Mahmood
AU - Singh Chauhan, Narendra Pal
AU - Khodadadi Yazdi, Mohsen
AU - Saeb, Mohammad Reza
AU - Ramsey, Joshua D.
AU - Hamblin, Michael R.
AU - Mozafari, Masoud
AU - Mostafavi, Ebrahim
N1 - Publisher Copyright:
© 2021 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.
PY - 2022/1
Y1 - 2022/1
N2 - There have been several attempts to find promising biomaterials for skin regeneration, among which polylysine (a homopolypeptide) has shown benefits in the regeneration and treatment of skin disorders. This class of biomaterials has shown exceptional abilities due to their macromolecular structure. Polylysine-based biomaterials can be used as tissue engineering scaffolds for skin regeneration, and as drug carriers or even gene delivery vectors for the treatment of skin diseases. In addition, polylysine can play a preservative role in extending the lifetime of skin tissue by minimizing the appearance of photodamaged skin. Research on polylysine is growing today, opening new scenarios that expand the potential of these biomaterials from traditional treatments to a new era of tissue regeneration. This review aims to address the basic concepts, recent trends, and prospects of polylysine-based biomaterials for skin regeneration. Undoubtedly, this class of biomaterials needs further evaluations and explorations, and many critical questions have yet to be answered.
AB - There have been several attempts to find promising biomaterials for skin regeneration, among which polylysine (a homopolypeptide) has shown benefits in the regeneration and treatment of skin disorders. This class of biomaterials has shown exceptional abilities due to their macromolecular structure. Polylysine-based biomaterials can be used as tissue engineering scaffolds for skin regeneration, and as drug carriers or even gene delivery vectors for the treatment of skin diseases. In addition, polylysine can play a preservative role in extending the lifetime of skin tissue by minimizing the appearance of photodamaged skin. Research on polylysine is growing today, opening new scenarios that expand the potential of these biomaterials from traditional treatments to a new era of tissue regeneration. This review aims to address the basic concepts, recent trends, and prospects of polylysine-based biomaterials for skin regeneration. Undoubtedly, this class of biomaterials needs further evaluations and explorations, and many critical questions have yet to be answered.
UR - http://www.scopus.com/inward/record.url?scp=85118477019&partnerID=8YFLogxK
U2 - 10.1002/btm2.10261
DO - 10.1002/btm2.10261
M3 - Review article
AN - SCOPUS:85118477019
SN - 2380-6761
VL - 7
JO - Bioengineering and Translational Medicine
JF - Bioengineering and Translational Medicine
IS - 1
M1 - e10261
ER -