TY - JOUR
T1 - Platinum(II) and gold(I) complexes based on 1,1′- bis(diphenylphosphino)metallocene derivatives
T2 - Synthesis, characterization and biological activity of the gold complexes
AU - Bjelosevic, Haris
AU - Guzei, Ilia A.
AU - Spencer, Lara C.
AU - Persson, Tina
AU - Kriel, Frederik H.
AU - Hewer, Raymond
AU - Nell, Margo J.
AU - Gut, Jiri
AU - Van Rensburg, Constance E.J.
AU - Rosenthal, Philip J.
AU - Coates, Judy
AU - Darkwa, James
AU - Elmroth, Sofi K.C.
PY - 2012/12/1
Y1 - 2012/12/1
N2 - The synthesis of series of 1,2,1′ substituted bis(diphenylphosphino)- ruthenocenyl (1-4) and ferrocenyl cis-platinum(II) (5-7) and gold(I) (8-12) complexes are described. Crystal structures of 2 and 4, as well as 5, 6 and 10 confirm the molecular geometry of these ligands and their metal complexes. Preliminary investigation of four gold complexes as potential anticancer, antiHIV and antimalaria showed at least one gold compound that has excellent activity towards one of these diseases. The three gold(I) complexes, {1- [1-(dimethylamino)ethyl]-1,2-bis(diphenylphosphino)ruthenocene- κ 2P,P′}bis[chlorogold(I)] (8) (IC 50 = 1.40 μM), {1-[1-(acetoxyethyl)-1′,2-bis(diphenylphosphino)ferrocene- κ 2P,P′]bis[chlorogold(I)] (9) (IC 50 = 0.51 μM), {1-[1-(3-carboxypropanamido)ethyl]-1′,2-bis(diphenylphosphino)- ruthenoceneκ 2P,P′}bis[chlorogold(I)] (12) (IC 50 = 1.784 μM), have the best activities against cancer, HIV and malaria respectively.
AB - The synthesis of series of 1,2,1′ substituted bis(diphenylphosphino)- ruthenocenyl (1-4) and ferrocenyl cis-platinum(II) (5-7) and gold(I) (8-12) complexes are described. Crystal structures of 2 and 4, as well as 5, 6 and 10 confirm the molecular geometry of these ligands and their metal complexes. Preliminary investigation of four gold complexes as potential anticancer, antiHIV and antimalaria showed at least one gold compound that has excellent activity towards one of these diseases. The three gold(I) complexes, {1- [1-(dimethylamino)ethyl]-1,2-bis(diphenylphosphino)ruthenocene- κ 2P,P′}bis[chlorogold(I)] (8) (IC 50 = 1.40 μM), {1-[1-(acetoxyethyl)-1′,2-bis(diphenylphosphino)ferrocene- κ 2P,P′]bis[chlorogold(I)] (9) (IC 50 = 0.51 μM), {1-[1-(3-carboxypropanamido)ethyl]-1′,2-bis(diphenylphosphino)- ruthenoceneκ 2P,P′}bis[chlorogold(I)] (12) (IC 50 = 1.784 μM), have the best activities against cancer, HIV and malaria respectively.
KW - AntiHIV
KW - Anticancer
KW - Antimalarial agents
KW - Bis(diphenylphosphino)ferrocenyl-
KW - Bis(diphenylphosphino)ruthenocenyl-
KW - Platinum and gold complexes
UR - http://www.scopus.com/inward/record.url?scp=84867540119&partnerID=8YFLogxK
U2 - 10.1016/j.jorganchem.2012.08.034
DO - 10.1016/j.jorganchem.2012.08.034
M3 - Article
AN - SCOPUS:84867540119
SN - 0022-328X
VL - 720
SP - 52
EP - 59
JO - Journal of Organometallic Chemistry
JF - Journal of Organometallic Chemistry
ER -
