Plant-based vaccines and cancer therapy: Where are we now and where are we going?

Neda Rahimian, Hamid Reza Miraei, Atefeh Amiri, Mohammad Saeid Ebrahimi, Javid Sadri Nahand, Hossein Tarrahimofrad, Michael R. Hamblin, Haroon Khan, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)


Therapeutic vaccines are an effective approach in cancer therapy for treating the disease at later stages. The Food and Drug Administration (FDA) recently approved the first therapeutic cancer vaccine, and further studies are ongoing in clinical trials. These are expected to result in the future development of vaccines with relatively improved efficacy. Several vaccination approaches are being studied in pre-clinical and clinical trials, including the generation of anti-cancer vaccines by plant expression systems.This approach has advantages, such as high safety and low costs, especially for the synthesis of recombinant proteins. Nevertheless, the development of anti-cancer vaccines in plants is faced with some technical obstacles.Herein, we summarize some vaccines that have been used in cancer therapy, with an emphasis on plant-based vaccines.

Original languageEnglish
Article number105655
JournalPharmacological Research
Publication statusPublished - Jul 2021


  • Cancer
  • Plant-based expression system
  • Recombinant proteins
  • Therapeutic vaccine

ASJC Scopus subject areas

  • Pharmacology


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