PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers

Omid Reza Tamtaji, Mohammad Behnam, Mohammad Ali Pourattar, Michael R. Hamblin, Maryam Mahjoubin-Tehran, Hamed Mirzaei, Zatollah Asemi

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma. [MediaObject not available: see fulltext.]

Original languageEnglish
Article number168
JournalCell Communication and Signaling
Volume18
Issue number1
DOIs
Publication statusPublished - 1 Dec 2020

Keywords

  • Apoptosis
  • Glioma
  • Invasion
  • Migration
  • PIWI protein
  • piRNAs

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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