PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers

Omid Reza Tamtaji; Mohammad Behnam; Mohammad Ali Pourattar; Michael R. Hamblin; Maryam Mahjoubin-Tehran; Hamed Mirzaei; Zatollah Asemi

doi:10.1186/s12964-020-00657-z

PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers

Omid Reza Tamtaji, Mohammad Behnam, Mohammad Ali Pourattar, Michael R. Hamblin, Maryam Mahjoubin-Tehran, Hamed Mirzaei, Zatollah Asemi

Laser Research Centre

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma. [MediaObject not available: see fulltext.]

Original language	English
Article number	168
Journal	Cell Communication and Signaling
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12964-020-00657-z
Publication status	Published - 1 Dec 2020

Keywords

Apoptosis
Glioma
Invasion
Migration
PIWI protein
piRNAs

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12964-020-00657-z

Cite this

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title = "PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers",

abstract = "Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma. [MediaObject not available: see fulltext.]",

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T1 - PIWI-interacting RNAs and PIWI proteins in glioma

T2 - molecular pathogenesis and role as biomarkers

AU - Tamtaji, Omid Reza

AU - Behnam, Mohammad

AU - Pourattar, Mohammad Ali

AU - Hamblin, Michael R.

AU - Mahjoubin-Tehran, Maryam

AU - Mirzaei, Hamed

AU - Asemi, Zatollah

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma. [MediaObject not available: see fulltext.]

AB - Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma. [MediaObject not available: see fulltext.]

KW - Apoptosis

KW - Glioma

KW - Invasion

KW - Migration

KW - PIWI protein

KW - piRNAs

UR - http://www.scopus.com/inward/record.url?scp=85094156538&partnerID=8YFLogxK

U2 - 10.1186/s12964-020-00657-z

DO - 10.1186/s12964-020-00657-z

M3 - Review article

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AN - SCOPUS:85094156538

SN - 1478-811X

VL - 18

JO - Cell Communication and Signaling

JF - Cell Communication and Signaling

IS - 1

M1 - 168

ER -

PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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