Physicochemical and in vitro cytotoxicity evaluation of polymeric drugs for combination cancer therapy

Blessing Atim Aderibigbe; Tobeka Naki; Vanessa Steenkamp; Mutshinyalo Nwamadi; Suprakas Sinha Ray; Mohammed Olusegun Balogun; William Morwa Reagile Matshe

doi:10.1080/00914037.2019.1667802

Physicochemical and in vitro cytotoxicity evaluation of polymeric drugs for combination cancer therapy

Blessing Atim Aderibigbe, Tobeka Naki, Vanessa Steenkamp, Mutshinyalo Nwamadi, Suprakas Sinha Ray, Mohammed Olusegun Balogun, William Morwa Reagile Matshe

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Platinum-based drugs are potent anticancer drugs and are effective for the treatment of various cancers. However, they are limited pharmacologically due to toxic side effects, drug resistance and poor water solubility. In order to overcome these limitations, platinum was incorporated onto polyamidoamine carriers together with alendronate and procaine hydrochloride to form a series of conjugates. Cytotoxicity was assessed using the sulforhodamine B assay on MCF-7, MDA-MB-231 and EA.hy926 cell lines. The polymer-drug conjugates showed cytotoxicity which was selective to the cancer cell lines. The free drugs decreased cell density in all cell lines and were nonspecific. These findings indicate that the incorporation of bioactive agents onto polymers can overcome cytotoxicity associated with the drugs. The selective inhibitory effects of the conjugates towards the cancer cell lines suggest that these conjugates are potential therapeutics for combination therapy.

Original language	English
Pages (from-to)	1134-1148
Number of pages	15
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	69
Issue number	17
DOIs	https://doi.org/10.1080/00914037.2019.1667802
Publication status	Published - 21 Nov 2020
Externally published	Yes

Keywords

Alendronate
cytotoxicity
platinum
polyamidoamine
polymer-drug conjugates
procaine

ASJC Scopus subject areas

Analytical Chemistry
General Chemical Engineering
Polymers and Plastics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/00914037.2019.1667802

Cite this

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title = "Physicochemical and in vitro cytotoxicity evaluation of polymeric drugs for combination cancer therapy",

abstract = "Platinum-based drugs are potent anticancer drugs and are effective for the treatment of various cancers. However, they are limited pharmacologically due to toxic side effects, drug resistance and poor water solubility. In order to overcome these limitations, platinum was incorporated onto polyamidoamine carriers together with alendronate and procaine hydrochloride to form a series of conjugates. Cytotoxicity was assessed using the sulforhodamine B assay on MCF-7, MDA-MB-231 and EA.hy926 cell lines. The polymer-drug conjugates showed cytotoxicity which was selective to the cancer cell lines. The free drugs decreased cell density in all cell lines and were nonspecific. These findings indicate that the incorporation of bioactive agents onto polymers can overcome cytotoxicity associated with the drugs. The selective inhibitory effects of the conjugates towards the cancer cell lines suggest that these conjugates are potential therapeutics for combination therapy.",

keywords = "Alendronate, cytotoxicity, platinum, polyamidoamine, polymer-drug conjugates, procaine",

author = "Aderibigbe, {Blessing Atim} and Tobeka Naki and Vanessa Steenkamp and Mutshinyalo Nwamadi and Ray, {Suprakas Sinha} and Balogun, {Mohammed Olusegun} and Matshe, {William Morwa Reagile}",

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T1 - Physicochemical and in vitro cytotoxicity evaluation of polymeric drugs for combination cancer therapy

AU - Aderibigbe, Blessing Atim

AU - Naki, Tobeka

AU - Steenkamp, Vanessa

AU - Nwamadi, Mutshinyalo

AU - Ray, Suprakas Sinha

AU - Balogun, Mohammed Olusegun

AU - Matshe, William Morwa Reagile

PY - 2020/11/21

Y1 - 2020/11/21

N2 - Platinum-based drugs are potent anticancer drugs and are effective for the treatment of various cancers. However, they are limited pharmacologically due to toxic side effects, drug resistance and poor water solubility. In order to overcome these limitations, platinum was incorporated onto polyamidoamine carriers together with alendronate and procaine hydrochloride to form a series of conjugates. Cytotoxicity was assessed using the sulforhodamine B assay on MCF-7, MDA-MB-231 and EA.hy926 cell lines. The polymer-drug conjugates showed cytotoxicity which was selective to the cancer cell lines. The free drugs decreased cell density in all cell lines and were nonspecific. These findings indicate that the incorporation of bioactive agents onto polymers can overcome cytotoxicity associated with the drugs. The selective inhibitory effects of the conjugates towards the cancer cell lines suggest that these conjugates are potential therapeutics for combination therapy.

AB - Platinum-based drugs are potent anticancer drugs and are effective for the treatment of various cancers. However, they are limited pharmacologically due to toxic side effects, drug resistance and poor water solubility. In order to overcome these limitations, platinum was incorporated onto polyamidoamine carriers together with alendronate and procaine hydrochloride to form a series of conjugates. Cytotoxicity was assessed using the sulforhodamine B assay on MCF-7, MDA-MB-231 and EA.hy926 cell lines. The polymer-drug conjugates showed cytotoxicity which was selective to the cancer cell lines. The free drugs decreased cell density in all cell lines and were nonspecific. These findings indicate that the incorporation of bioactive agents onto polymers can overcome cytotoxicity associated with the drugs. The selective inhibitory effects of the conjugates towards the cancer cell lines suggest that these conjugates are potential therapeutics for combination therapy.

KW - Alendronate

KW - cytotoxicity

KW - platinum

KW - polyamidoamine

KW - polymer-drug conjugates

KW - procaine

UR - http://www.scopus.com/inward/record.url?scp=85074040797&partnerID=8YFLogxK

U2 - 10.1080/00914037.2019.1667802

DO - 10.1080/00914037.2019.1667802

M3 - Article

AN - SCOPUS:85074040797

SN - 0091-4037

VL - 69

SP - 1134

EP - 1148

JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

IS - 17

ER -

Physicochemical and in vitro cytotoxicity evaluation of polymeric drugs for combination cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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