TY - JOUR
T1 - Photothermal Depth Profiling of Gelatin-Stabilised Gold Nanorods-Trastuzumab Conjugate as a Potential Breast Cancer Photothermal Agent
AU - Mwad Mbaz, Gracia It
AU - Calvin Lebepe, Thabang
AU - Maluleke, Rodney
AU - Obonai, Akiyoshi
AU - Mgedle, Nande
AU - Aladesuyi, Olanrewaju A.
AU - Kalimutu, Rajendran
AU - Kodama, Tetsuya
AU - Komiya, Atsuki
AU - Oluwafemi, Oluwatobi Samuel
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/11
Y1 - 2024/11
N2 - Gold nanorods (AuNRs) are powerful photothermal agents (PTAs) in cancer treatment due to their near-infrared laser light absorption ability. However, the cytotoxicity of AuNRs caused by the presence of cationic surfactants often used and their lack of specificity affect their application in photothermal therapy. Thus, we herein developed a bioconjugate obtained from the functionalisation of AuNRs to gelatin (Gel@AuNRs), followed by the conjugation of the as-synthesised material to a breast cancer antibody, trastuzumab (Trast-Gel@AuNRs) to address these issues. The optical and structural characterization of the as-synthesized indicated no significant changes in the optical properties of AuNRs after their functionalisation with gelatin and conjugation with the antibody. The photothermal profiling of the as-synthesised materials showed that AuNRs still have an excellent photothermal conversion efficiency (PCE) after their functionalisation (20%) and their conjugation to an antibody (19%). In addition, the In vitro photothermal depth response showed that Trast-Gel@AuNRs is a promising photothermal agent for HER2-positive breast cancer treatment.
AB - Gold nanorods (AuNRs) are powerful photothermal agents (PTAs) in cancer treatment due to their near-infrared laser light absorption ability. However, the cytotoxicity of AuNRs caused by the presence of cationic surfactants often used and their lack of specificity affect their application in photothermal therapy. Thus, we herein developed a bioconjugate obtained from the functionalisation of AuNRs to gelatin (Gel@AuNRs), followed by the conjugation of the as-synthesised material to a breast cancer antibody, trastuzumab (Trast-Gel@AuNRs) to address these issues. The optical and structural characterization of the as-synthesized indicated no significant changes in the optical properties of AuNRs after their functionalisation with gelatin and conjugation with the antibody. The photothermal profiling of the as-synthesised materials showed that AuNRs still have an excellent photothermal conversion efficiency (PCE) after their functionalisation (20%) and their conjugation to an antibody (19%). In addition, the In vitro photothermal depth response showed that Trast-Gel@AuNRs is a promising photothermal agent for HER2-positive breast cancer treatment.
KW - Breast cancer
KW - Gold nanorods
KW - Photothermal profiling
KW - Trastuzumab
UR - http://www.scopus.com/inward/record.url?scp=85197433730&partnerID=8YFLogxK
U2 - 10.1007/s10904-024-03151-y
DO - 10.1007/s10904-024-03151-y
M3 - Article
AN - SCOPUS:85197433730
SN - 1574-1443
VL - 34
SP - 5491
EP - 5502
JO - Journal of Inorganic and Organometallic Polymers and Materials
JF - Journal of Inorganic and Organometallic Polymers and Materials
IS - 11
ER -
