Phototherapy promotes healing of cutaneous wounds in undernourished rats

Saulo Nani Leite, Thiago Antônio Moretti de Andrade, Daniela dos Santos Masson-Meyers, Marcel Nani Leite, Chukuka S. Enwemeka, Marco Andrey Cipriani Frade

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background: Various studies have shown that phototherapy promotes the healing of cutaneous wounds.

Objective: To investigate the effect of phototherapy on healing of cutaneous wounds in nourished and undernourished rats.

Methods: Forty rats, 20 nourished plus 20 others rendered marasmus with undernourishment, were assigned to four equal groups: nourished sham, nourished Light Emitting Diode treated, undernourished sham and undernourished Light Emitting Diode treated. In the two treated groups, two 8-mm punch wounds made on the dorsum of each rat were irradiated three times per week with 3 J/cm2 sq cm of combined 660 and 890nm light; wounds in the other groups were not irradiated. Wounds were evaluated with digital photography and image analysis, either on day 7 or day 14, with biopsies obtained on day 14 for histological studies.

Results: Undernourishment retarded the mean healing rate of the undernourished sham wounds (p < 0.01), but not the undernourished Light emission diode treated wounds, which healed significantly faster (p < 0.001) and as fast as the two nourished groups. Histological analysis showed a smaller percentage of collagen in the undernourished sham group compared with the three other groups, thus confirming our photographic image analysis data.

Conclusion: Phototherapy reverses the adverse healing effects of undernourishment. Similar beneficial effects may be achieved in patients with poor nutritional status.

Original languageEnglish
Pages (from-to)899-904
Number of pages6
JournalAnais Brasileiros de Dermatologia
Issue number6
Publication statusPublished - 1 Nov 2014
Externally publishedYes


  • Nutritional marasmus
  • Phototherapy
  • Protein malnutrition
  • Wound healing

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Phototherapy promotes healing of cutaneous wounds in undernourished rats'. Together they form a unique fingerprint.

Cite this