TY - JOUR
T1 - Phototherapy promotes healing of cutaneous wounds in undernourished rats
AU - Leite, Saulo Nani
AU - de Andrade, Thiago Antônio Moretti
AU - Masson-Meyers, Daniela dos Santos
AU - Leite, Marcel Nani
AU - Enwemeka, Chukuka S.
AU - Frade, Marco Andrey Cipriani
N1 - Publisher Copyright:
© 2014 by Anais Brasileiros de Dermatologia.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Background: Various studies have shown that phototherapy promotes the healing of cutaneous wounds.Objective: To investigate the effect of phototherapy on healing of cutaneous wounds in nourished and undernourished rats.Methods: Forty rats, 20 nourished plus 20 others rendered marasmus with undernourishment, were assigned to four equal groups: nourished sham, nourished Light Emitting Diode treated, undernourished sham and undernourished Light Emitting Diode treated. In the two treated groups, two 8-mm punch wounds made on the dorsum of each rat were irradiated three times per week with 3 J/cm2 sq cm of combined 660 and 890nm light; wounds in the other groups were not irradiated. Wounds were evaluated with digital photography and image analysis, either on day 7 or day 14, with biopsies obtained on day 14 for histological studies.Results: Undernourishment retarded the mean healing rate of the undernourished sham wounds (p < 0.01), but not the undernourished Light emission diode treated wounds, which healed significantly faster (p < 0.001) and as fast as the two nourished groups. Histological analysis showed a smaller percentage of collagen in the undernourished sham group compared with the three other groups, thus confirming our photographic image analysis data.Conclusion: Phototherapy reverses the adverse healing effects of undernourishment. Similar beneficial effects may be achieved in patients with poor nutritional status.
AB - Background: Various studies have shown that phototherapy promotes the healing of cutaneous wounds.Objective: To investigate the effect of phototherapy on healing of cutaneous wounds in nourished and undernourished rats.Methods: Forty rats, 20 nourished plus 20 others rendered marasmus with undernourishment, were assigned to four equal groups: nourished sham, nourished Light Emitting Diode treated, undernourished sham and undernourished Light Emitting Diode treated. In the two treated groups, two 8-mm punch wounds made on the dorsum of each rat were irradiated three times per week with 3 J/cm2 sq cm of combined 660 and 890nm light; wounds in the other groups were not irradiated. Wounds were evaluated with digital photography and image analysis, either on day 7 or day 14, with biopsies obtained on day 14 for histological studies.Results: Undernourishment retarded the mean healing rate of the undernourished sham wounds (p < 0.01), but not the undernourished Light emission diode treated wounds, which healed significantly faster (p < 0.001) and as fast as the two nourished groups. Histological analysis showed a smaller percentage of collagen in the undernourished sham group compared with the three other groups, thus confirming our photographic image analysis data.Conclusion: Phototherapy reverses the adverse healing effects of undernourishment. Similar beneficial effects may be achieved in patients with poor nutritional status.
KW - Nutritional marasmus
KW - Phototherapy
KW - Protein malnutrition
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=84909971228&partnerID=8YFLogxK
U2 - 10.1590/abd1806-4841.20143356
DO - 10.1590/abd1806-4841.20143356
M3 - Article
C2 - 25387494
AN - SCOPUS:84909971228
SN - 0365-0596
VL - 89
SP - 899
EP - 904
JO - Anais Brasileiros de Dermatologia
JF - Anais Brasileiros de Dermatologia
IS - 6
ER -