Photostable fluorescent Near-infrared colloidal Mn-doped CuInSe/ZnS quantum dots for cancer-bacteria dual imaging

Vuyelwa Ncapayi, Neethu Ninan, Thabang C. Lebepe, Sundararajan Parani, Aswathy Ravindran Girija, Richard Bright, Rodney Maluleke, Olanrewaju A. Aladesuyi, Tetsuya Kodama, Krasimir Vasilev, Oluwatobi S. Oluwafemi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Near-infrared quantum dots (NIR QDs) with tunable fluorescence emission are promising materials for bioimaging applications. However, they face several challenges, including low photostability, reduced brightness, and poor fluorescence emission. Herein, we report the synthesis of NIR emitting colloidal Mn-doped CuInSe/ZnS QDs synthesised via the hydrothermal method in a commercial pressure cooker. These fluorescent materials had a peak corresponding to photoluminescence maxima at 765 nm and had good photostability. The in vitro analysis showed that the as-synthesised QDs displayed good cell viability against mouse colon carcinoma (C26) cells. They selectively screened Gram-positive bacteria from Gram-negative bacteria and effectively targeted prostate cancer cells compared to normal cells. Thus, they can be used for cancer-bacteria dual-imaging in the biomedical field.

Original languageEnglish
Article number119785
JournalJournal of Luminescence
Volume258
DOIs
Publication statusPublished - Jun 2023

Keywords

  • Bacteria
  • Bioimaging
  • Manganese doping
  • Near-infrared quantum dots
  • Prostate cancer

ASJC Scopus subject areas

  • Biophysics
  • Atomic and Molecular Physics, and Optics
  • General Chemistry
  • Biochemistry
  • Condensed Matter Physics

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