Photostable fluorescent Near-infrared colloidal Mn-doped CuInSe/ZnS quantum dots for cancer-bacteria dual imaging

Vuyelwa Ncapayi; Neethu Ninan; Thabang C. Lebepe; Sundararajan Parani; Aswathy Ravindran Girija; Richard Bright; Rodney Maluleke; Olanrewaju A. Aladesuyi; Tetsuya Kodama; Krasimir Vasilev; Oluwatobi S. Oluwafemi

doi:10.1016/j.jlumin.2023.119785

Photostable fluorescent Near-infrared colloidal Mn-doped CuInSe/ZnS quantum dots for cancer-bacteria dual imaging

Vuyelwa Ncapayi, Neethu Ninan, Thabang C. Lebepe, Sundararajan Parani, Aswathy Ravindran Girija, Richard Bright, Rodney Maluleke, Olanrewaju A. Aladesuyi, Tetsuya Kodama, Krasimir Vasilev, Oluwatobi S. Oluwafemi

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Near-infrared quantum dots (NIR QDs) with tunable fluorescence emission are promising materials for bioimaging applications. However, they face several challenges, including low photostability, reduced brightness, and poor fluorescence emission. Herein, we report the synthesis of NIR emitting colloidal Mn-doped CuInSe/ZnS QDs synthesised via the hydrothermal method in a commercial pressure cooker. These fluorescent materials had a peak corresponding to photoluminescence maxima at 765 nm and had good photostability. The in vitro analysis showed that the as-synthesised QDs displayed good cell viability against mouse colon carcinoma (C26) cells. They selectively screened Gram-positive bacteria from Gram-negative bacteria and effectively targeted prostate cancer cells compared to normal cells. Thus, they can be used for cancer-bacteria dual-imaging in the biomedical field.

Original language	English
Article number	119785
Journal	Journal of Luminescence
Volume	258
DOIs	https://doi.org/10.1016/j.jlumin.2023.119785
Publication status	Published - Jun 2023

Keywords

Bacteria
Bioimaging
Manganese doping
Near-infrared quantum dots
Prostate cancer

ASJC Scopus subject areas

Biophysics
Atomic and Molecular Physics, and Optics
General Chemistry
Biochemistry
Condensed Matter Physics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jlumin.2023.119785

Cite this

@article{c67cf9dca4514f3cbec5d85677da6d32,

title = "Photostable fluorescent Near-infrared colloidal Mn-doped CuInSe/ZnS quantum dots for cancer-bacteria dual imaging",

abstract = "Near-infrared quantum dots (NIR QDs) with tunable fluorescence emission are promising materials for bioimaging applications. However, they face several challenges, including low photostability, reduced brightness, and poor fluorescence emission. Herein, we report the synthesis of NIR emitting colloidal Mn-doped CuInSe/ZnS QDs synthesised via the hydrothermal method in a commercial pressure cooker. These fluorescent materials had a peak corresponding to photoluminescence maxima at 765 nm and had good photostability. The in vitro analysis showed that the as-synthesised QDs displayed good cell viability against mouse colon carcinoma (C26) cells. They selectively screened Gram-positive bacteria from Gram-negative bacteria and effectively targeted prostate cancer cells compared to normal cells. Thus, they can be used for cancer-bacteria dual-imaging in the biomedical field.",

keywords = "Bacteria, Bioimaging, Manganese doping, Near-infrared quantum dots, Prostate cancer",

author = "Vuyelwa Ncapayi and Neethu Ninan and Lebepe, {Thabang C.} and Sundararajan Parani and Girija, {Aswathy Ravindran} and Richard Bright and Rodney Maluleke and Aladesuyi, {Olanrewaju A.} and Tetsuya Kodama and Krasimir Vasilev and Oluwafemi, {Oluwatobi S.}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

month = jun,

doi = "10.1016/j.jlumin.2023.119785",

language = "English",

volume = "258",

journal = "Journal of Luminescence",

issn = "0022-2313",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Photostable fluorescent Near-infrared colloidal Mn-doped CuInSe/ZnS quantum dots for cancer-bacteria dual imaging

AU - Ncapayi, Vuyelwa

AU - Ninan, Neethu

AU - Lebepe, Thabang C.

AU - Parani, Sundararajan

AU - Girija, Aswathy Ravindran

AU - Bright, Richard

AU - Maluleke, Rodney

AU - Aladesuyi, Olanrewaju A.

AU - Kodama, Tetsuya

AU - Vasilev, Krasimir

AU - Oluwafemi, Oluwatobi S.

PY - 2023/6

Y1 - 2023/6

N2 - Near-infrared quantum dots (NIR QDs) with tunable fluorescence emission are promising materials for bioimaging applications. However, they face several challenges, including low photostability, reduced brightness, and poor fluorescence emission. Herein, we report the synthesis of NIR emitting colloidal Mn-doped CuInSe/ZnS QDs synthesised via the hydrothermal method in a commercial pressure cooker. These fluorescent materials had a peak corresponding to photoluminescence maxima at 765 nm and had good photostability. The in vitro analysis showed that the as-synthesised QDs displayed good cell viability against mouse colon carcinoma (C26) cells. They selectively screened Gram-positive bacteria from Gram-negative bacteria and effectively targeted prostate cancer cells compared to normal cells. Thus, they can be used for cancer-bacteria dual-imaging in the biomedical field.

AB - Near-infrared quantum dots (NIR QDs) with tunable fluorescence emission are promising materials for bioimaging applications. However, they face several challenges, including low photostability, reduced brightness, and poor fluorescence emission. Herein, we report the synthesis of NIR emitting colloidal Mn-doped CuInSe/ZnS QDs synthesised via the hydrothermal method in a commercial pressure cooker. These fluorescent materials had a peak corresponding to photoluminescence maxima at 765 nm and had good photostability. The in vitro analysis showed that the as-synthesised QDs displayed good cell viability against mouse colon carcinoma (C26) cells. They selectively screened Gram-positive bacteria from Gram-negative bacteria and effectively targeted prostate cancer cells compared to normal cells. Thus, they can be used for cancer-bacteria dual-imaging in the biomedical field.

KW - Bacteria

KW - Bioimaging

KW - Manganese doping

KW - Near-infrared quantum dots

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=85150075330&partnerID=8YFLogxK

U2 - 10.1016/j.jlumin.2023.119785

DO - 10.1016/j.jlumin.2023.119785

M3 - Article

AN - SCOPUS:85150075330

SN - 0022-2313

VL - 258

JO - Journal of Luminescence

JF - Journal of Luminescence

M1 - 119785

ER -

Photostable fluorescent Near-infrared colloidal Mn-doped CuInSe/ZnS quantum dots for cancer-bacteria dual imaging

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Reports from University of Johannesburg Describe Recent Advances in Cancer (Photostable Fluorescent Near-infrared Colloidal Mn-doped Cuinse/zns Quantum Dots for Cancer-bacteria Dual Imaging)

Cite this

Photostable fluorescent Near-infrared colloidal Mn-doped CuInSe/ZnS quantum dots for cancer-bacteria dual imaging

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Press/Media

Reports from University of Johannesburg Describe Recent Advances in Cancer (Photostable Fluorescent Near-infrared Colloidal Mn-doped Cuinse/zns Quantum Dots for Cancer-bacteria Dual Imaging)

Cite this