Abstract
Photoimmunotherapy (PIT), which involves the antibody-targeted delivery of a photosensitizer and subsequent illumination, might offer a new treatment option for ovarian cancer. Studies from our laboratory and those of others show the specific killing of ovarian cancer cells in vitro and ex vivo by photoimmunoconjugates directed against the ovarian cancer specific antigen CA125. In vivo studies in nude mice with human xenografts, show an increased survival after photoimmunotherapy. In addition, it was shown in ex vivo studies that PIT in combination with cisplatinum, significantly decreases cell viability, especially in platinum-resistant cells. These data suggest further exploration of PIT as an option for the treatment of intraperitoneal disease.
| Original language | English |
|---|---|
| Pages (from-to) | 30-33 |
| Number of pages | 4 |
| Journal | Proceedings of SPIE - The International Society for Optical Engineering |
| Volume | 3909 |
| Publication status | Published - 2000 |
| Externally published | Yes |
| Event | Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX - San Jose, CA, USA Duration: 22 Jan 2000 → 23 Jan 2000 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering
