Photodynamic therapy with hexa(sulfo-n-butyl)[60]fullerene against sarcoma in vitro and in vivo

Chi Yu, Pinar Avci, Taizoon Canteenwala, Long Y. Chiang, Bao J. Chen, Michael R. Hamblin

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


The hydrophilic molecular micellar hexa(sulfo-n-butyl)[60]fullerene (FC4S), first synthesized in 1998 as a photosensitizer (PS) has been reported to exhibit high efficacy for singlet oxygen generation and antimicrobial photodynamic inactivation. The purpose of this study was to investigate the effects of photoactivated FC4S for free radical generation and to mediate photodynamic therapy (PDT) of cancer in vitro and in vivo. The results demonstrated that following light irradiation, FC4S produced singlet oxygen, but after addition of electron donors such as ferrocytochrome c or NADH, FC4S also produced superoxide. The combination of FC4S with light irradiation was able to induce cytotoxicity to human fibrosarcoma cells and murine sarcoma 180 cells in vitro. Cell-killing was proportional to fluence as well as FC4S concentration. Photoirradiation by argon-ion laser after intraperitoneal injection of FC4S also resulted in inhibition of S180 tumor growth in vivo (up to 80% reduction of tumor volume). Hematological and blood biochemistry parameters of the cancer-bearing mice were improved by PDT. Based on these findings, we conclude that FC4S has a great potential as a nanomedicine in PDT for cancer.

Original languageEnglish
Pages (from-to)171-181
Number of pages11
JournalJournal of Nanoscience and Nanotechnology
Issue number1
Publication statusPublished - 1 Jan 2016
Externally publishedYes


  • Hydrophilic hexa(sulfo-n-butyl)[60]fullerene (FCS)
  • ICR Mice
  • Photodynamic therapy
  • Reactive oxygen species
  • S180 murine sarcoma

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • Biomedical Engineering
  • General Materials Science
  • Condensed Matter Physics


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