Photodynamic Therapy (PDT) in drug delivery: Nano-innovations enhancing treatment outcomes

Ahmed N. Al-Jamal; Ali Fawzi Al-Hussainy; Bahira Abdulrazzaq Mohammed; Hadi Hussein Abbas; Issa Mohammed Kadhim; Zahraa Hassan Ward; Debarshi Kar Mahapatra; Tomy Muringayil Joseph; Ehsan kianfar; Sabu Thomas

doi:10.1016/j.hsr.2025.100218

Photodynamic Therapy (PDT) in drug delivery: Nano-innovations enhancing treatment outcomes

Ahmed N. Al-Jamal
, Ali Fawzi Al-Hussainy
, Bahira Abdulrazzaq Mohammed
, Hadi Hussein Abbas
, Issa Mohammed Kadhim
, Zahraa Hassan Ward
, Debarshi Kar Mahapatra
, Tomy Muringayil Joseph
, Ehsan kianfar
, Sabu Thomas

Chemical Sciences

University of Babylon
Ahl Al Bayt University
Al-Hadi University College
Al-Manara College for Medical Sciences
Al-Nisour University College
Mazaya University College
Shri Rawatpura Sarkar Institute of Pharmacy
Gdańsk University of Technology
Islamic Azad University
Trivandrum Engineering Science & Technology Research Park
Mahatma Gandhi University, Kottayam

Research output: Contribution to journal › Review article › peer-review

48 Citations (Scopus)

Abstract

One approach to treating cancer and other infections is Photodynamic Therapy (PDT). Numerous treatment modalities including PDT have long recognized the need to improve the performance of nanoscale therapeutic frameworks. Photosensitizers (Ps) are NPs used in PDT, selectively targeting malignant tissues for therapeutic effects, while sparing healthy cells. Using NPs as a carrier might be a great achievement since these NPs have all the necessary components for an ideal PDT operator. The review explores various types of NPs used in PDT. It also depicts the subsequent advancements in the use of inorganic NPs and NPs derived from biodegradable polymers. Varieties of dynamic NPs including those that upconvert, self-radiate, and photosynthesize are now under review.

Original language	English
Article number	100218
Journal	Health Sciences Review
Volume	14
DOIs	https://doi.org/10.1016/j.hsr.2025.100218
Publication status	Published - Mar 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Light therapy
Photodynamic
Photosynthesize
Quantum dots
Therapy

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/j.hsr.2025.100218

Cite this

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title = "Photodynamic Therapy (PDT) in drug delivery: Nano-innovations enhancing treatment outcomes",

abstract = "One approach to treating cancer and other infections is Photodynamic Therapy (PDT). Numerous treatment modalities including PDT have long recognized the need to improve the performance of nanoscale therapeutic frameworks. Photosensitizers (Ps) are NPs used in PDT, selectively targeting malignant tissues for therapeutic effects, while sparing healthy cells. Using NPs as a carrier might be a great achievement since these NPs have all the necessary components for an ideal PDT operator. The review explores various types of NPs used in PDT. It also depicts the subsequent advancements in the use of inorganic NPs and NPs derived from biodegradable polymers. Varieties of dynamic NPs including those that upconvert, self-radiate, and photosynthesize are now under review.",

keywords = "Light therapy, Photodynamic, Photosynthesize, Quantum dots, Therapy",

author = "Al-Jamal, \{Ahmed N.\} and Al-Hussainy, \{Ali Fawzi\} and Mohammed, \{Bahira Abdulrazzaq\} and Abbas, \{Hadi Hussein\} and Kadhim, \{Issa Mohammed\} and Ward, \{Zahraa Hassan\} and Mahapatra, \{Debarshi Kar\} and Joseph, \{Tomy Muringayil\} and Ehsan kianfar and Sabu Thomas",

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year = "2025",

month = mar,

doi = "10.1016/j.hsr.2025.100218",

language = "English",

volume = "14",

journal = "Health Sciences Review",

issn = "2772-6320",

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T2 - Nano-innovations enhancing treatment outcomes

AU - Al-Jamal, Ahmed N.

AU - Al-Hussainy, Ali Fawzi

AU - Mohammed, Bahira Abdulrazzaq

AU - Abbas, Hadi Hussein

AU - Kadhim, Issa Mohammed

AU - Ward, Zahraa Hassan

AU - Mahapatra, Debarshi Kar

AU - Joseph, Tomy Muringayil

AU - kianfar, Ehsan

AU - Thomas, Sabu

PY - 2025/3

Y1 - 2025/3

N2 - One approach to treating cancer and other infections is Photodynamic Therapy (PDT). Numerous treatment modalities including PDT have long recognized the need to improve the performance of nanoscale therapeutic frameworks. Photosensitizers (Ps) are NPs used in PDT, selectively targeting malignant tissues for therapeutic effects, while sparing healthy cells. Using NPs as a carrier might be a great achievement since these NPs have all the necessary components for an ideal PDT operator. The review explores various types of NPs used in PDT. It also depicts the subsequent advancements in the use of inorganic NPs and NPs derived from biodegradable polymers. Varieties of dynamic NPs including those that upconvert, self-radiate, and photosynthesize are now under review.

AB - One approach to treating cancer and other infections is Photodynamic Therapy (PDT). Numerous treatment modalities including PDT have long recognized the need to improve the performance of nanoscale therapeutic frameworks. Photosensitizers (Ps) are NPs used in PDT, selectively targeting malignant tissues for therapeutic effects, while sparing healthy cells. Using NPs as a carrier might be a great achievement since these NPs have all the necessary components for an ideal PDT operator. The review explores various types of NPs used in PDT. It also depicts the subsequent advancements in the use of inorganic NPs and NPs derived from biodegradable polymers. Varieties of dynamic NPs including those that upconvert, self-radiate, and photosynthesize are now under review.

KW - Light therapy

KW - Photodynamic

KW - Photosynthesize

KW - Quantum dots

KW - Therapy

UR - https://www.scopus.com/pages/publications/105018889577

U2 - 10.1016/j.hsr.2025.100218

DO - 10.1016/j.hsr.2025.100218

M3 - Review article

AN - SCOPUS:105018889577

SN - 2772-6320

VL - 14

JO - Health Sciences Review

JF - Health Sciences Review

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ER -

Photodynamic Therapy (PDT) in drug delivery: Nano-innovations enhancing treatment outcomes

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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