Photodynamic therapy and photobiomodulation: Can all diseases be treated with light?

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)

Abstract

Visible and near-infrared light may be able to treat all (or nearly all) human diseases. Light plus nontoxic dyes called photosensitizers (PS) can kill cancer cells, inactivate a broad-spectrum of pathogens and destroy unwanted tissue using a process called photodynamic therapy (PDT). The mechanism involves photochemical generation of a range of reactive oxygen species including singlet oxygen and hydroxyl radicals. Due to the alarming worldwide rise in multi-antibiotic resistance in bacteria. PDT has emerged as a promising alternative for localized infections. It has been observed that antigen-specific immune response against cancer can be potentiated by PDT. Moreover a non-specific protective immune response against infection has also been observed. In contrast light alone in a process called photobiomodulation (PBM) or low level light therapy (LLLT) can reduce inflammation and pain, stimulate healing and tissue repair. Mechanisms involve photon absorption in mitochondrial cytochrome c oxidase, melanopsin, and transient receptor potential ion channels. Stem cells are particularly sensitized to light activation. Many different diseases and injuries can be benefited including wound healing, arthritis, spinal cord injury, muscle fatigue, and neuropathic pain. Brain disorders respond very well, such as traumatic brain injury, Alzheimer’s disease, depression, and PTSD. PBM can increase brain-derived neurotrophic factor, neurogenesis, and synaptogenesis.

Original languageEnglish
Title of host publicationEncyclopedia of Modern Optics
PublisherElsevier
Pages100-135
Number of pages36
Volume1-5
ISBN (Electronic)9780128149829
ISBN (Print)9780128092835
DOIs
Publication statusPublished - 1 Jan 2018
Externally publishedYes

Keywords

  • Anti-tumor immunity
  • Antimicrobial photodynamic inactivation
  • Mechanisms of PBM
  • PBM for brain disorders
  • PDT for cancer
  • PDT for infection
  • Photobiomodulation
  • Photodynamic therapy

ASJC Scopus subject areas

  • General Engineering
  • General Materials Science

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