Photodynamic therapy and anti-tumour immunity

Ana P. Castano; Pawel Mroz; Michael R. Hamblin

doi:10.1038/nrc1894

Photodynamic therapy and anti-tumour immunity

Ana P. Castano, Pawel Mroz, Michael R. Hamblin

Research output: Contribution to journal › Review article › peer-review

2454 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.

Original language	English
Pages (from-to)	535-545
Number of pages	11
Journal	Nature Reviews Cancer
Volume	6
Issue number	7
DOIs	https://doi.org/10.1038/nrc1894
Publication status	Published - Jul 2006
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrc1894

Cite this

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title = "Photodynamic therapy and anti-tumour immunity",

abstract = "Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.",

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AU - Mroz, Pawel

AU - Hamblin, Michael R.

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AB - Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.

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U2 - 10.1038/nrc1894

DO - 10.1038/nrc1894

M3 - Review article

C2 - 16794636

AN - SCOPUS:33745537921

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JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

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Photodynamic therapy and anti-tumour immunity

Abstract

ASJC Scopus subject areas

UN SDGs

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