Photobiomodulation in Neuronal Cell Cultures

Farzad Salehpour, Saeed Sadigh-Eteghad, Javad Mahmoudi, Farzin Kamari, Paolo Cassano, Michael Richard Hamblin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


This chapter delves into the application of photobiomodulation (PBM) in neuronal cell cultures, focusing on the importance of in vitro studies and the various cellular mechanisms affected by this treatment approach. Section 1 discusses the importance of in vitro studies, highlighting their value in providing controlled environments for the investigation of PBM’s effects on neuronal cells. In vitro models allow researchers to isolate specific factors, test various treatment parameters, and elucidate underlying cellular and molecular mechanisms. Section 2 presents an overview of in vitro PBM studies, organized into several subsections discussing the different cellular mechanisms impacted by PBM. These mechanisms include cytochrome c oxidase activity, nitric oxide modulation, reactive oxygen species modulation, mitochondrial membrane potential regulation, and Ca2+ regulation. Overall, this chapter provides a comprehensive understanding of PBM’s effects on neuronal cell cultures, emphasizing the importance of in vitro studies for elucidating the cellular and molecular mechanisms underlying this therapeutic approach.

Original languageEnglish
Title of host publicationSynthesis Lectures on Biomedical Engineering
PublisherSpringer Nature
Number of pages21
Publication statusPublished - 2023

Publication series

NameSynthesis Lectures on Biomedical Engineering
VolumePart F1286
ISSN (Print)1930-0328
ISSN (Electronic)1930-0336

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Biomedical Engineering


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