Photobiomodulation and mitochondria for traumatic brain injury in mouse models

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)


This chapter covers two studies conducted in the Wu laboratory. Immediate early response gene (IEX-1) is an immediate early response gene involved in maintaining mitochondrial function. The first study looked at mice with IEX-1 deficiency, and asked whether a traumatic brain injury (TBI) inflicted on these mice would be more or less severe than it was in wild-type (WT) mice. IEX-1 KO mice suffered worse pathological and cognitive outcome after TBI than WT mice, and interestingly transcranial photobiomodulation (tPBM) was able to rescue these mice from the effects of the TBI. The second study looked at a combination of tPBM and the metabolic modulators (pyruvate and lactate). The combination of tPBM with either pyruvate or lactate, synergistically improved brain function both in vitro and in vivo in TBI mice.

Original languageEnglish
Title of host publicationPhotobiomodulation in the Brain
Subtitle of host publicationLow-Level Laser (Light) Therapy in Neurology and Neuroscience
Number of pages19
ISBN (Electronic)9780128153055
ISBN (Print)9780128153062
Publication statusPublished - 1 Jan 2019
Externally publishedYes


  • Immediate early response gene (IEX-1) knock-out mice
  • Lactate and pyruvate
  • Metabolic modulators
  • Mitochondrial dysfunction
  • Neuroinflammation
  • TBI
  • Transcranial photobiomodulation

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Photobiomodulation and mitochondria for traumatic brain injury in mouse models'. Together they form a unique fingerprint.

Cite this