Perspective: The potential of pyrazole-based compounds in medicine

Frankline K. Keter, James Darkwa

Research output: Contribution to journalReview articlepeer-review

206 Citations (Scopus)

Abstract

Pyrazoles are widely used as core motifs for a large number of compounds for various applications such as catalysis, agro-chemicals, building blocks of other compounds and in medicine. The attractiveness of pyrazole and its derivatives is their versatility that allows for synthesis of a series of analogues with different moieties in them, thus affecting the electronics and by extension the properties of the resultant compounds. In medicine pyrazole is found as a pharmacophore in some of the active biological molecules. While pyrazole derivatives have been extensively studied for many applications including anticancer, antimicrobial, anti-inflammatory, antiglycemic, anti-allergy and antiviral, much less has been reported on their metal counterparts in spite of the fact that metals have been shown to impart activity to ligands. Thus this perspective is intended to demonstrate the potential of pyrazole and pyrazolyl metal complexes in the areas of drug discovery and development. Several examples, that include palladium, platinum, copper, gold, zinc, cobalt, nickel, iron, copper, silver and gallium complexes, are used to bolster the above point. For the purposes of this review three areas are discussed, that is pyrazole metal complexes as: (i) anticancer, (ii) antibacterial/parasitic and (iii) antiviral agents.

Original languageEnglish
Pages (from-to)9-21
Number of pages13
JournalBioMetals
Volume25
Issue number1
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Antibacterial
  • Anticancer
  • Antiparasitic
  • Antiviral
  • Metal complexes
  • Pyrazole

ASJC Scopus subject areas

  • Biomaterials
  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • Metals and Alloys

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