TY - JOUR
T1 - PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy
AU - Abedi-Gaballu, Fereydoon
AU - Dehghan, Gholamreza
AU - Ghaffari, Maryam
AU - Yekta, Reza
AU - Abbaspour-Ravasjani, Soheil
AU - Baradaran, Behzad
AU - Ezzati Nazhad Dolatabadi, Jafar
AU - Hamblin, Michael R.
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/9
Y1 - 2018/9
N2 - Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have indiscriminate cytotoxicity that affects normal, as well as cancer cells. To overcome these problems, new more efficient nanosystems for drug delivery are increasingly being investigated. Polyamidoamine (PAMAM) dendrimers are an example of a versatile and reproducible type of nanocarrier that can be loaded with drugs, and modified by attaching target-specific ligands that recognize receptors that are over-expressed on cancer cells. PAMAM dendrimers with a high density of cationic charges display electrostatic interactions with nucleic acids (DNA, siRNA, miRNA, etc.), creating dendriplexes that can preserve the nucleic acids from degradation. Dendrimers are prepared by conducting several successive “generations” of synthetic reactions so their size can be easily controlled and they have good uniformity. Dendrimers are particularly well-suited to co-delivery applications (simultaneous delivery of drugs and/or genes). In the current review, we discuss dendrimer-based targeted delivery of drugs/genes and co-delivery systems mainly for cancer therapy.
AB - Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have indiscriminate cytotoxicity that affects normal, as well as cancer cells. To overcome these problems, new more efficient nanosystems for drug delivery are increasingly being investigated. Polyamidoamine (PAMAM) dendrimers are an example of a versatile and reproducible type of nanocarrier that can be loaded with drugs, and modified by attaching target-specific ligands that recognize receptors that are over-expressed on cancer cells. PAMAM dendrimers with a high density of cationic charges display electrostatic interactions with nucleic acids (DNA, siRNA, miRNA, etc.), creating dendriplexes that can preserve the nucleic acids from degradation. Dendrimers are prepared by conducting several successive “generations” of synthetic reactions so their size can be easily controlled and they have good uniformity. Dendrimers are particularly well-suited to co-delivery applications (simultaneous delivery of drugs and/or genes). In the current review, we discuss dendrimer-based targeted delivery of drugs/genes and co-delivery systems mainly for cancer therapy.
KW - Co-delivery
KW - Gene delivery
KW - Nanovehicles
KW - PAMAM dendrimers
KW - Targeted drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85047632559&partnerID=8YFLogxK
U2 - 10.1016/j.apmt.2018.05.002
DO - 10.1016/j.apmt.2018.05.002
M3 - Review article
AN - SCOPUS:85047632559
SN - 2352-9407
VL - 12
SP - 177
EP - 190
JO - Applied Materials Today
JF - Applied Materials Today
ER -
