Palladium-catalyzed Heck reactions promoted by limonene-derived bicyclic phosphines

Boitumelo Setati, Paseka Thendo Moshapo, Cedric Wahl Holzapfel, Munaka Christopher Maumela

Research output: Contribution to journalArticlepeer-review


Tertiary bicyclic phosphines derived from (R)-(+)-limonene provided efficient palladium catalysts for Heck cross-coupling reactions. Overall, high yields of the desired aryl alkenes products were obtained for cross-coupling of sterically and electronically diverse substrates. The efficiency of the catalysts was further demonstrated in the synthesis of commercial ketones, such as raspberry ketone and its derivatives.

Original languageEnglish
Pages (from-to)1477-1489
Number of pages13
JournalSynthetic Communications
Issue number13-14
Publication statusPublished - 2022


  • Catalysis
  • Heck-reaction
  • cross-coupling
  • limonene
  • palladium
  • phosphine ligands

ASJC Scopus subject areas

  • Organic Chemistry


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